Detailed information of TA system TA059572

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 1657539..1658050
• Replicon: chromosome
• Accession: NZ_CP013911
• Organism: Staphylococcus haemolyticus strain S167

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: Q4L7W7
• Locus tag: AV904_RS08005
• Protein ID: WP_011275259.1
• Coordinates: 1657539..1657745 (-)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: AV904_RS08010
• Protein ID: WP_011275258.1
• Coordinates: 1657757..1658050 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AV904_RS07990	1652658..1653728	-	1071	WP_011275263.1	D-alanine--D-alanine ligase	-
AV904_RS07995	1654146..1655345	+	1200	WP_011275262.1	rod shape-determining protein RodA	-
AV904_RS08000	1655303..1656997	-	1695	WP_062931985.1	IS1182 family transposase	-
AV904_RS12640	1657294..1657431	-	138	WP_011275260.1	hypothetical protein	-
AV904_RS08005	1657539..1657745	-	207	WP_011275259.1	heavy-metal-associated domain-containing protein	Toxin
AV904_RS08010	1657757..1658050	-	294	WP_011275258.1	copper-sensing transcriptional repressor CsoR	Antitoxin
AV904_RS08015	1658237..1659721	+	1485	WP_011275257.1	cardiolipin synthase	-
AV904_RS08020	1659821..1660462	+	642	WP_016931420.1	HD domain-containing protein	-
AV904_RS08025	1660511..1661827	-	1317	WP_062931986.1	ISL3 family transposase	-
AV904_RS08030	1662022..1662897	-	876	WP_011275255.1	membrane protein insertase YidC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	SCCmec	-	groEL	1262607..1692661	430054
	-	inside	IScluster/Tn	-	-	1655303..1661827	6524

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7857.79 Da
• Isoelectric Point: 4.0742

>T59572 WP_011275259.1 NZ_CP013911:c1657745-1657539 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T59572 NZ_CP013911:c1657745-1657539 [Staphylococcus haemolyticus]
ATGAACTTTAGTGAAATTAGAATTAGTGAATTAAATACTGAAGAGCAAGCTAATTCACTCCAACATAGACTTGAGAAGAT
GATAGGTGTAGATGAAGTAATTGTAGAACTAAATGACCAATTAGTTAAAATTTCTTATGAAACACCTACGAATTTAAATA
GTATTGAAAAAGAAATTTATGATGATGGTTATAAGGTATTAGGTTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11222.83 Da
• Isoelectric Point: 6.6361

>AT59572 WP_011275258.1 NZ_CP013911:c1658050-1657757 [Staphylococcus haemolyticus]
MNNHENAHHSDQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT59572 NZ_CP013911:c1658050-1657757 [Staphylococcus haemolyticus]
TTGAATAATCATGAAAATGCACATCATTCCGATCAAATTAAAATGAATTTAAAATCAAGACTTAATCGTATTGAAGGGCA
AGTTAGAGCGATTAATCGCATGATTGAAGAAGATGTATACTGTGATGACGTGCTAACTCAAATTAGAGCTACAAGATCAG
CTTTAAATAGTGTGGCCACTAAGTTGCTAGATCATCATATGAAAAGCTGTATCATGGATAAAGTGAATAACGGCGCTCAA
GAAGAAGCGATGGAAGAATTGTTAGTGACTTTTCAAAAATTAATGAAAGATTAG

Structures

Toxin

• AlphaFold DB: A0A2A1K7I8