Detailed information of TA system TA059570

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1500417..1501188
• Replicon: chromosome
• Accession: NZ_CP013911
• Organism: Staphylococcus haemolyticus strain S167

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: AV904_RS12830
• Protein ID: WP_011275410.1
• Coordinates: 1500417..1500566 (-)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: Q4L7F8
• Locus tag: AV904_RS07150
• Protein ID: WP_011275409.1
• Coordinates: 1500589..1501188 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AV904_RS07130	1496032..1497141	-	1110	WP_011275414.1	GAF domain-containing sensor histidine kinase	-
AV904_RS07135	1497329..1498153	+	825	WP_011275413.1	RluA family pseudouridine synthase	-
AV904_RS07140	1498219..1499604	-	1386	WP_011275412.1	class II fumarate hydratase	-
AV904_RS07145	1499811..1500206	-	396	WP_011275411.1	hypothetical protein	-
AV904_RS12830	1500417..1500566	-	150	WP_011275410.1	hypothetical protein	Toxin
AV904_RS07150	1500589..1501188	-	600	WP_011275409.1	glucosamine-6-phosphate isomerase	Antitoxin
AV904_RS07155	1501360..1501830	-	471	WP_016931343.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
AV904_RS07160	1501831..1502958	-	1128	WP_011275407.1	tRNA epoxyqueuosine(34) reductase QueG	-
AV904_RS07165	1503136..1503837	-	702	WP_053038723.1	amino acid ABC transporter ATP-binding protein	-
AV904_RS07170	1503852..1505279	-	1428	WP_053038724.1	ABC transporter substrate-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	SCCmec	-	groEL	1262607..1692661	430054

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5796.18 Da
• Isoelectric Point: 3.9484

>T59570 WP_011275410.1 NZ_CP013911:c1500566-1500417 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDKLNQSHE

Nucleotide

• Length: 150 bp

>T59570 NZ_CP013911:c1500566-1500417 [Staphylococcus haemolyticus]
ATGACTAAAAATAAAGATTCAGAATTAAATTATCATGAGGAAGAAAATGCGATGGTTCAAGATTTAGATGACTTGAAAAC
CTTGGGTAAAGAAATGGAACAAATTTCTGAAGAAAACGACGAGGACAAGTTGAATCAATCGCATGAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22272.12 Da
• Isoelectric Point: 4.7588

>AT59570 WP_011275409.1 NZ_CP013911:c1501188-1500589 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PASQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPSDLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT59570 NZ_CP013911:c1501188-1500589 [Staphylococcus haemolyticus]
ATGGCAATGAACTTTAAAGTATTTAATGATGTAGAACATGTAGCTGAGTACACAGCAGATATCATTAGAAAGCAATTTAA
TAATAACCCTACAACTATTGCGGGAATTCATTTAACAAAGGATGCTGCACCTGTTTTAGATGAGTTAAAGAAAGATGTAG
ATCATAATGCGGTTGATTTTAGTCAAGTAAATATCTTAGATTATGACGATAATCGCTCTTACTATGAAGCATTAGGTGTA
CCTGCTAGTCAAATTTATCCAATTAATCTTGACGATGATGCAGAATCTTTAATTGATGACAAAATTAAAACTAAAGAAAA
TAAAGGTAAATTAATTTTACAAGTTACTTCTATTGATGAATCAGGTAGTTTAAATGTAAATGTAAGACAAGGATTATTAA
AAGCGCGTGAAGTAGTATTAGTTGTGACTGGTGCTAATAAACGTGAAGTTGTTAAAAAACTTTATGAAGAAAATGGTAAA
TCTAGCTTTGAACCATCTGATTTAAAAGCTCATAGAATGGTAACAGTTGTTTTAGATAGAGCAGCTGCAGAAGGTTTACC
TGAGGATGTTAAAGAATATTTCACTGCTAGATTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2A1K9C2