59569

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 573048..573516 Replicon chromosome
Accession NZ_CP013911
Organism Staphylococcus haemolyticus strain S167

Toxin (Protein)


Gene name TsaT Uniprot ID Q4L4Q4
Locus tag AV904_RS02825 Protein ID WP_011276326.1
Coordinates 573048..573236 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID Q4L4Q5
Locus tag AV904_RS02830 Protein ID WP_011276325.1
Coordinates 573259..573516 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AV904_RS02790 568756..568980 - 225 WP_011276334.1 hypothetical protein -
AV904_RS02795 569226..569513 - 288 WP_011276333.1 hypothetical protein -
AV904_RS02800 569589..570335 - 747 WP_011276332.1 poly-gamma-glutamate hydrolase family protein -
AV904_RS02805 570472..571080 + 609 WP_011276331.1 GNAT family N-acetyltransferase -
AV904_RS02810 571149..571895 - 747 WP_037558435.1 membrane lipoprotein lipid attachment site-containing protein -
AV904_RS02815 572065..572301 + 237 WP_016931008.1 hypothetical protein -
AV904_RS02820 572349..572930 - 582 WP_011276327.1 hypothetical protein -
AV904_RS02825 573048..573236 - 189 WP_011276326.1 hypothetical protein Toxin
AV904_RS02830 573259..573516 - 258 WP_011276325.1 hypothetical protein Antitoxin
AV904_RS02835 574067..574270 + 204 WP_033079647.1 sterile alpha motif-like domain-containing protein -
AV904_RS02840 574262..574504 - 243 WP_011276324.1 hypothetical protein -
AV904_RS02845 574732..575340 + 609 WP_011276323.1 phosphoglycerate mutase family protein -
AV904_RS02850 575527..576144 - 618 WP_011276322.1 LysE/ArgO family amino acid transporter -
AV904_RS02855 576276..576767 - 492 WP_011276321.1 GNAT family N-acetyltransferase -
AV904_RS02860 577030..577452 - 423 WP_016931015.1 organic hydroperoxide resistance protein -
AV904_RS02865 577615..578340 + 726 WP_037558439.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 520006..586644 66638


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7110.80 Da        Isoelectric Point: 9.6269

>T59569 WP_011276326.1 NZ_CP013911:c573236-573048 [Staphylococcus haemolyticus]
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL

Download         Length: 189 bp

>T59569 NZ_CP013911:c573236-573048 [Staphylococcus haemolyticus]
ATGAGTTTGCATTTAACTATATTGTTATGGCTTGGTATCATTTTTGTAATAGCAGCCTCAATTATATTGGGCTTATTACT
TAAATCTAAAAAAGAAGAACGTAAAGAATCATATTTAGGTTTTACCGTAATATTTTATATTTTTGGATTTGCTTTACTCA
TCTACGTATTCATATTTGGTATATTATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9914.97 Da        Isoelectric Point: 4.0625

>AT59569 WP_011276325.1 NZ_CP013911:c573516-573259 [Staphylococcus haemolyticus]
MNNNKIFWINIFMTLLFLGFNIIVTYNADLDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIVMLLYYIYPM
VYTFF

Download         Length: 258 bp

>AT59569 NZ_CP013911:c573516-573259 [Staphylococcus haemolyticus]
ATGAATAATAATAAAATTTTTTGGATAAATATTTTTATGACGCTATTATTTTTGGGTTTCAATATCATTGTCACTTACAA
TGCAGACTTAGATGATTTCTTCTGGCTAATTCCAGGACTGACAATTAGTGGTATCACAATTGTACTAAGCTTAAGTACTG
CGCTCATTTGCAAGAACCTGGTTAGCGAAGTTATTTTTCTAATCAATATTGTTATGCTTTTATACTACATTTATCCTATG
GTATATACATTCTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KAB5

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1KAX9

References