59565

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(antitoxin)
Location 2203278..2203855 Replicon chromosome
Accession NZ_CP013909
Organism Hymenobacter sedentarius strain DG5B

Toxin (Protein)


Gene name mazF Uniprot ID A0A0U4AWZ0
Locus tag AUC43_RS09225 Protein ID WP_068192200.1
Coordinates 2203598..2203855 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0U4AAR8
Locus tag AUC43_RS09220 Protein ID WP_068192198.1
Coordinates 2203278..2203610 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AUC43_RS09210 2198613..2201957 + 3345 WP_099092888.1 hypothetical protein -
AUC43_RS09215 2202229..2203095 - 867 WP_082685009.1 sugar phosphate isomerase/epimerase -
AUC43_RS09220 2203278..2203610 - 333 WP_068192198.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
AUC43_RS09225 2203598..2203855 - 258 WP_068192200.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
AUC43_RS09230 2204067..2205209 - 1143 WP_068192203.1 serine hydrolase -
AUC43_RS09235 2205306..2205605 + 300 WP_068192205.1 transposase -
AUC43_RS09240 2205674..2206480 + 807 WP_157781013.1 IS3 family transposase -
AUC43_RS09245 2206685..2207917 + 1233 WP_068192209.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(7-108)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.98 Da        Isoelectric Point: 4.7769

>T59565 WP_068192200.1 NZ_CP013909:c2203855-2203598 [Hymenobacter sedentarius]
MNTRLIRVGNSQGIVLPKKLLQQYHLAGEVDLRPTPEGLLITPVAPPRRQDWDARFQHAIAQGQTPEGELLEGFADDFEE
SEWRW

Download         Length: 258 bp

>T59565 NZ_CP013909:c2203855-2203598 [Hymenobacter sedentarius]
ATGAACACGCGCCTGATTCGGGTGGGCAATTCCCAGGGGATTGTGCTGCCCAAGAAGTTACTGCAGCAGTATCACTTGGC
TGGGGAGGTCGACCTGCGGCCCACTCCCGAGGGCCTGCTCATCACCCCGGTGGCCCCGCCCCGCCGCCAAGATTGGGACG
CGCGCTTTCAGCACGCCATTGCCCAAGGGCAAACGCCGGAGGGAGAGCTGCTGGAAGGCTTCGCCGACGACTTCGAGGAA
AGCGAATGGCGGTGGTAG

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12453.38 Da        Isoelectric Point: 8.2688

>AT59565 WP_068192198.1 NZ_CP013909:c2203610-2203278 [Hymenobacter sedentarius]
MAVVGVLRFEVWLVNLDPTQGSEINKTRPCVVVSPDEMNRYLRTVTIAALTSTRRDYPSRVDCTFQGQEGQVALDHVRSV
DKTRLVRLLGVLPKATAQAVCERLQEMFQY

Download         Length: 333 bp

>AT59565 NZ_CP013909:c2203610-2203278 [Hymenobacter sedentarius]
ATGGCGGTGGTAGGCGTGCTGCGCTTCGAGGTGTGGCTCGTCAACCTCGACCCGACCCAGGGCAGCGAAATCAACAAGAC
CCGCCCCTGCGTGGTGGTCTCCCCCGACGAGATGAACCGCTACCTGCGCACGGTCACGATTGCCGCGCTCACCAGCACCC
GGCGCGACTACCCCTCGCGGGTGGACTGCACCTTCCAGGGCCAGGAGGGCCAGGTCGCGCTCGACCACGTGCGGTCCGTG
GACAAGACGCGGTTGGTGCGCCTCTTGGGCGTGCTGCCCAAGGCCACGGCCCAGGCTGTCTGCGAGCGCTTGCAGGAAAT
GTTTCAGTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U4AWZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A0U4AAR8

References