Detailed information of TA system TA059564

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 2037131..2037755
• Replicon: chromosome
• Accession: NZ_CP013908
• Organism: Streptococcus agalactiae strain GBS-M002

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A076ZDW1
• Locus tag: AV644_RS10550
• Protein ID: WP_000253103.1
• Coordinates: 2037131..2037478 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A076YVN5
• Locus tag: AV644_RS10555
• Protein ID: WP_000543070.1
• Coordinates: 2037468..2037755 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AV644_RS10530	2032846..2033202	-	357	WP_000105935.1	DUF1304 domain-containing protein	-
AV644_RS10535	2033269..2035587	-	2319	WP_000883417.1	YhgE/Pip domain-containing protein	-
AV644_RS10540	2035726..2036265	+	540	WP_000245858.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
AV644_RS10545	2036351..2036647	-	297	WP_001052249.1	DUF4298 domain-containing protein	-
AV644_RS10550	2037131..2037478	-	348	WP_000253103.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AV644_RS10555	2037468..2037755	-	288	WP_000543070.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
AV644_RS10560	2037824..2038201	-	378	WP_000038826.1	DUF1492 domain-containing protein	-
AV644_RS11080	2038176..2038328	-	153	Protein_1950	DUF1492 domain-containing protein	-
AV644_RS10565	2038335..2038823	-	489	WP_000891152.1	hypothetical protein	-
AV644_RS10570	2038896..2039453	-	558	WP_001258764.1	hypothetical protein	-
AV644_RS10575	2039611..2039784	-	174	WP_000694573.1	hypothetical protein	-
AV644_RS10580	2039781..2040038	-	258	WP_001069293.1	hypothetical protein	-
AV644_RS10585	2040331..2041725	-	1395	WP_000656430.1	hypothetical protein	-
AV644_RS10590	2041737..2042594	-	858	WP_001029296.1	primase alpha helix C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2016942..2073978	57036

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-63)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13333.09 Da
• Isoelectric Point: 5.1643

>T59564 WP_000253103.1 NZ_CP013908:c2037478-2037131 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Nucleotide

• Length: 348 bp

>T59564 NZ_CP013908:c2037478-2037131 [Streptococcus agalactiae]
TTGGTATCTGATAATAAAACCCATAGCCTTATTATCCCTGAAACCGTACAAGAACAATTACAGGAGATAAAAAGCTATAT
TGAAACTACTTACTTTTCGGAGCAGGCAGGGGCTAACACCGTCAACAATATTCTTTACGGGCTAGAACGTCTTGAATTTT
TCCCAGAAGCAGGATTTAACGCAGATGACAGAGTAGGTGAAACTATTTACCCGCCACATAATACTCGTTGTATTGTTTTA
GGGGACTACCTAGCTTTTTATCACATTTTAGAAGACAGAAAAGCCGTTTTTGTATCTGATATTATCCATAGCAAACAAGA
CTATATCAAACTGTTTAAGAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10605.98 Da
• Isoelectric Point: 4.8430

>AT59564 WP_000543070.1 NZ_CP013908:c2037755-2037468 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Nucleotide

• Length: 288 bp

>AT59564 NZ_CP013908:c2037755-2037468 [Streptococcus agalactiae]
ATGCACGCTTTAGAAAAAAATACGCAGGTCAACTTTAAAACCAACAGTGATTTACTAGAGAAAGCTAAAGCTATTATCGC
AGCCCAAAACCTTGACATGACAGCTAGCTTTAATTTGTTTTTAGAAAACATTGTACAAAATAAAGCCTTACCTTTTGAGA
CTGACACCGATAAAGAACGAGCTGAACTACTTGCAGGTTTACGAGCTGAAATTGCTAAAAGTTTTGACGATTTAGAGCAT
GGGCGGGTATACAACGCTAGTGAAGTGAGGGCTAACCTTGGTATCTGA

Structures

Toxin

• AlphaFold DB: A0A076ZDW1

Antitoxin

• AlphaFold DB: A0A076YVN5