Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1061953..1062620 Replicon chromosome
Accession NZ_CP013859
Organism Microbacterium sp. XT11

Toxin (Protein)


Gene name vapC Uniprot ID A0A0U4FKX2
Locus tag AB663_RS05035 Protein ID WP_067196379.1
Coordinates 1061953..1062372 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0U3XVH2
Locus tag AB663_RS05040 Protein ID WP_067196381.1
Coordinates 1062369..1062620 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB663_RS05015 1057126..1058286 - 1161 WP_083511113.1 glutamate--cysteine ligase -
AB663_RS17115 1058283..1058420 - 138 WP_157540886.1 hypothetical protein -
AB663_RS05020 1058484..1058819 - 336 WP_198147931.1 winged helix DNA-binding protein -
AB663_RS05025 1059014..1059337 + 324 WP_198147932.1 hypothetical protein -
AB663_RS17340 1059385..1059522 - 138 WP_198147933.1 hypothetical protein -
AB663_RS05030 1059553..1061883 - 2331 WP_067196377.1 phosphoribosylformylglycinamidine synthase subunit PurL -
AB663_RS05035 1061953..1062372 - 420 WP_067196379.1 type II toxin-antitoxin system VapC family toxin Toxin
AB663_RS05040 1062369..1062620 - 252 WP_067196381.1 hypothetical protein Antitoxin
AB663_RS05045 1062695..1063621 - 927 WP_157541232.1 WYL domain-containing protein -
AB663_RS05050 1063757..1064227 + 471 WP_067196385.1 VOC family protein -
AB663_RS05055 1064401..1065561 + 1161 WP_067196387.1 arsenic transporter -
AB663_RS05060 1065587..1066300 - 714 WP_157541235.1 SGNH/GDSL hydrolase family protein -
AB663_RS05065 1066318..1067493 - 1176 WP_067196391.1 DUF4185 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15390.77 Da        Isoelectric Point: 4.9057

>T59472 WP_067196379.1 NZ_CP013859:c1062372-1061953 [Microbacterium sp. XT11]
MIVLDTNVLSEFMRSRPSERVRKWLDGIPEREVWTTTVVIAEIAAGIALLPQGARRRVLAEEFDRMLQLFADRILVFDAS
AAVEYGTIVAYRARLGRPISIADAQIAAIVTVNGAVLATRNVTDFDGLTVDLVDPWHSP

Download         Length: 420 bp

>T59472 NZ_CP013859:c1062372-1061953 [Microbacterium sp. XT11]
ATGATCGTCCTCGACACCAACGTCCTGTCGGAGTTCATGCGATCGCGGCCGAGCGAGCGCGTGCGGAAATGGCTCGACGG
GATCCCCGAGCGCGAGGTGTGGACGACGACCGTTGTGATCGCCGAGATCGCGGCGGGCATCGCCCTTCTCCCGCAGGGCG
CCCGCAGACGAGTCCTCGCCGAGGAGTTCGATCGGATGCTGCAGCTCTTCGCAGACCGCATCCTGGTGTTCGATGCGAGT
GCGGCGGTCGAGTACGGAACCATCGTGGCGTACCGCGCACGGCTCGGACGCCCCATCAGCATCGCCGACGCGCAGATCGC
GGCCATCGTGACCGTGAACGGGGCGGTGCTCGCGACTCGCAACGTCACCGACTTCGACGGCCTCACGGTCGACCTCGTCG
ACCCCTGGCACAGCCCATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8927.15 Da        Isoelectric Point: 6.3057

>AT59472 WP_067196381.1 NZ_CP013859:c1062620-1062369 [Microbacterium sp. XT11]
MATITVRGLDDDVVRALKMSAAREGRSMEAEIRSILTAAARRASSPPPRVGEGFGTRLASIFSDGTALEVPPRDDYPRPL
DLT

Download         Length: 252 bp

>AT59472 NZ_CP013859:c1062620-1062369 [Microbacterium sp. XT11]
ATGGCCACGATCACCGTGCGTGGGCTCGACGACGATGTCGTACGAGCCCTCAAGATGAGCGCAGCGCGTGAAGGACGCTC
CATGGAAGCCGAGATCCGCAGCATCCTGACCGCCGCCGCTCGTCGCGCTTCTTCGCCGCCGCCACGCGTGGGCGAAGGAT
TCGGCACCCGCCTCGCTTCGATCTTCTCCGACGGCACGGCGCTCGAGGTCCCTCCCCGCGACGACTATCCCCGACCGCTC
GATCTCACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U4FKX2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3XVH2

References