Detailed information of TA system TA059468

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1473331..1473943
• Replicon: chromosome
• Accession: NZ_CP013839
• Organism: Streptococcus pyogenes strain MGAS23530

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MGAS23530_RS07140
• Protein ID: WP_002994716.1
• Coordinates: 1473608..1473943 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: MGAS23530_RS07135
• Protein ID: WP_002988079.1
• Coordinates: 1473331..1473618 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MGAS23530_RS07110	1468510..1469493	-	984	WP_031488719.1	tagatose-bisphosphate aldolase	-
MGAS23530_RS07115	1469497..1470426	-	930	WP_031488720.1	tagatose-6-phosphate kinase	-
MGAS23530_RS07120	1470474..1470989	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
MGAS23530_RS07125	1471024..1471452	-	429	WP_014635709.1	galactose-6-phosphate isomerase subunit LacA	-
MGAS23530_RS07130	1471897..1472670	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
MGAS23530_RS07135	1473331..1473618	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
MGAS23530_RS07140	1473608..1473943	+	336	WP_002994716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MGAS23530_RS08780	1474095..1474565	+	471	WP_021733374.1	site-specific integrase	-
MGAS23530_RS08785	1474528..1475076	+	549	WP_180372715.1	site-specific integrase	-
MGAS23530_RS07150	1475208..1475600	-	393	WP_002982716.1	30S ribosomal protein S9	-
MGAS23530_RS07155	1475621..1476067	-	447	WP_002982710.1	50S ribosomal protein L13	-
MGAS23530_RS07160	1476285..1476491	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
MGAS23530_RS07165	1476488..1476994	-	507	WP_002988070.1	hypothetical protein	-
MGAS23530_RS07170	1477130..1477990	-	861	WP_011529009.1	DegV family protein	-
MGAS23530_RS07175	1478087..1478605	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13154.89 Da
• Isoelectric Point: 5.6157

>T59468 WP_002994716.1 NZ_CP013839:1473608-1473943 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T59468 NZ_CP013839:1473608-1473943 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT59468 WP_002988079.1 NZ_CP013839:1473331-1473618 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT59468 NZ_CP013839:1473331-1473618 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94