Detailed information of TA system TA059465

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 5024828..5025648
• Replicon: chromosome
• Accession: NZ_CP013835
• Organism: Escherichia coli strain JJ2434

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: AVR68_RS26250
• Protein ID: WP_001054379.1
• Coordinates: 5025391..5025648 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: AVR68_RS26245
• Protein ID: WP_000123957.1
• Coordinates: 5024828..5025379 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AVR68_RS26220	5020522..5021835	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
AVR68_RS26225	5021847..5022125	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
AVR68_RS26230	5022122..5023243	-	1122	WP_000010833.1	M42 family metallopeptidase	-
AVR68_RS30555	5023488..5023604	-	117	Protein_4794	VOC family protein	-
AVR68_RS26235	5023642..5023902	-	261	WP_000077645.1	hypothetical protein	-
AVR68_RS26240	5024030..5024776	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
AVR68_RS26245	5024828..5025379	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
AVR68_RS26250	5025391..5025648	-	258	WP_001054379.1	YjhX family toxin	Toxin
AVR68_RS28810	5026025..5026189	-	165	Protein_4799	GNAT family N-acetyltransferase	-
AVR68_RS26265	5027432..5028538	+	1107	Protein_4801	helicase YjhR	-
AVR68_RS26270	5029121..5030101	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T59465 WP_001054379.1 NZ_CP013835:c5025648-5025391 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T59465 NZ_CP013835:c5025648-5025391 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT59465 WP_000123957.1 NZ_CP013835:c5025379-5024828 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT59465 NZ_CP013835:c5025379-5024828 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030