Detailed information of TA system TA059413

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4970038..4970858
• Replicon: chromosome
• Accession: NZ_CP013831
• Organism: Escherichia coli strain CD306

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: AVR67_RS24875
• Protein ID: WP_001054379.1
• Coordinates: 4970601..4970858 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: AVR67_RS24870
• Protein ID: WP_000123957.1
• Coordinates: 4970038..4970589 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AVR67_RS24845	4965732..4967045	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
AVR67_RS24850	4967057..4967335	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
AVR67_RS24855	4967332..4968453	-	1122	WP_000010833.1	M42 family metallopeptidase	-
AVR67_RS29730	4968698..4968814	-	117	Protein_4736	VOC family protein	-
AVR67_RS24860	4968852..4969112	-	261	WP_000077645.1	hypothetical protein	-
AVR67_RS24865	4969240..4969986	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
AVR67_RS24870	4970038..4970589	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
AVR67_RS24875	4970601..4970858	-	258	WP_001054379.1	YjhX family toxin	Toxin
AVR67_RS28045	4971235..4971399	-	165	Protein_4741	GNAT family N-acetyltransferase	-
AVR67_RS24890	4972642..4973748	+	1107	Protein_4743	helicase YjhR	-
AVR67_RS24895	4974331..4975311	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T59413 WP_001054379.1 NZ_CP013831:c4970858-4970601 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T59413 NZ_CP013831:c4970858-4970601 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT59413 WP_000123957.1 NZ_CP013831:c4970589-4970038 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT59413 NZ_CP013831:c4970589-4970038 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030