Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4936065..4936900 Replicon chromosome
Accession NZ_CP013831
Organism Escherichia coli strain CD306

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag AVR67_RS24710 Protein ID WP_000854759.1
Coordinates 4936523..4936900 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag AVR67_RS24705 Protein ID WP_001295723.1
Coordinates 4936065..4936433 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVR67_RS24675 4933180..4933338 + 159 WP_001323397.1 DUF905 family protein -
AVR67_RS24680 4933493..4934311 + 819 WP_001234738.1 DUF945 domain-containing protein -
AVR67_RS24685 4934653..4935126 + 474 WP_001350782.1 antirestriction protein -
AVR67_RS24690 4935142..4935618 + 477 WP_001186775.1 RadC family protein -
AVR67_RS24695 4935681..4935902 + 222 WP_000692345.1 DUF987 domain-containing protein -
AVR67_RS24705 4936065..4936433 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AVR67_RS24710 4936523..4936900 + 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
AVR67_RS24715 4936897..4937385 + 489 WP_000761690.1 hypothetical protein -
AVR67_RS24720 4937402..4937578 + 177 WP_000839286.1 DUF957 domain-containing protein -
AVR67_RS24725 4937768..4938514 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
AVR67_RS24730 4938529..4940070 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
AVR67_RS29340 4940789..4940965 + 177 Protein_4713 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T59412 WP_000854759.1 NZ_CP013831:4936523-4936900 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T59412 NZ_CP013831:4936523-4936900 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT59412 WP_001295723.1 NZ_CP013831:4936065-4936433 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT59412 NZ_CP013831:4936065-4936433 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References