Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 1348699..1349244 Replicon chromosome
Accession NZ_CP013826
Organism Vibrio parahaemolyticus strain FORC_018

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag FORC18_RS06775 Protein ID WP_053047111.1
Coordinates 1348699..1348995 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag FORC18_RS06780 Protein ID WP_053047112.1
Coordinates 1349002..1349244 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC18_RS06730 1344152..1344775 + 624 WP_015296930.1 hypothetical protein -
FORC18_RS06735 1344953..1345309 + 357 WP_020198239.1 hypothetical protein -
FORC18_RS24915 1345343..1345434 + 92 Protein_1203 DUF3265 domain-containing protein -
FORC18_RS06740 1345488..1345883 + 396 WP_024699538.1 hypothetical protein -
FORC18_RS06745 1346024..1346782 + 759 WP_053047185.1 hypothetical protein -
FORC18_RS06750 1346797..1346889 + 93 WP_071936843.1 DUF3265 domain-containing protein -
FORC18_RS06755 1346920..1347354 + 435 WP_029849895.1 hypothetical protein -
FORC18_RS06760 1347374..1347466 + 93 WP_071936844.1 DUF3265 domain-containing protein -
FORC18_RS06765 1348022..1348531 + 510 WP_031849426.1 GNAT family N-acetyltransferase -
FORC18_RS25550 1348546..1348637 + 92 Protein_1210 DUF3265 domain-containing protein -
FORC18_RS06775 1348699..1348995 - 297 WP_053047111.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC18_RS06780 1349002..1349244 - 243 WP_053047112.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FORC18_RS06785 1349492..1350370 + 879 WP_053047187.1 DUF4145 domain-containing protein -
FORC18_RS06790 1350371..1350484 + 114 WP_071936845.1 DUF3265 domain-containing protein -
FORC18_RS06795 1350521..1351018 + 498 WP_053047113.1 hypothetical protein -
FORC18_RS06800 1351033..1351125 + 93 WP_071936820.1 DUF3265 domain-containing protein -
FORC18_RS06805 1351159..1351599 + 441 WP_053047189.1 GNAT family N-acetyltransferase -
FORC18_RS06810 1351748..1352194 + 447 WP_053047114.1 GNAT family N-acetyltransferase -
FORC18_RS06815 1352353..1353075 + 723 WP_053047191.1 hypothetical protein -
FORC18_RS06820 1353218..1353790 + 573 WP_053047193.1 hypothetical protein -
FORC18_RS06825 1353805..1353897 + 93 WP_082241140.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1284450..1390555 106105
- inside Integron - - 1284974..1361671 76697


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-55)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11275.94 Da        Isoelectric Point: 9.3813

>T59384 WP_053047111.1 NZ_CP013826:c1348995-1348699 [Vibrio parahaemolyticus]
MQKNKYKLSKLAQAHLLKIKNYTVNNFSEMQWRNYKDTLLTGFQMLADNPEVGRSCDDIYPNGFHFPVGKHAAYFTKEDG
FILVVAVLGQSQLPQNHL

Download         Length: 297 bp

>T59384 NZ_CP013826:c1348995-1348699 [Vibrio parahaemolyticus]
ATGCAAAAGAATAAATATAAACTAAGTAAATTAGCTCAGGCTCATTTATTAAAAATCAAAAACTATACCGTTAATAACTT
TTCAGAGATGCAGTGGCGCAACTACAAAGATACGTTACTGACTGGATTTCAGATGCTTGCTGACAATCCGGAAGTTGGTC
GAAGTTGCGATGACATTTACCCAAACGGGTTTCACTTCCCCGTTGGTAAGCACGCAGCTTACTTTACAAAAGAAGACGGC
TTCATTTTGGTTGTAGCTGTACTCGGTCAGTCACAATTACCGCAAAACCACTTATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8986.22 Da        Isoelectric Point: 5.1131

>AT59384 WP_053047112.1 NZ_CP013826:c1349244-1349002 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLKHCFESAKEDLAQGNVVNGEDFLRAL

Download         Length: 243 bp

>AT59384 NZ_CP013826:c1349244-1349002 [Vibrio parahaemolyticus]
ATGCACACATTAACAGCAAATGATGCAAAACGTAATTTTGGTGAGCTTCTTCTGAGCGCACAACGTGAGCCAGTAAAAAT
TAGCAAAAACAGCAAAGATGCCGTAGTTGTAATGTCTATTAAAGATTATGAAGAGCTAGAAGCTATGAAAGCTGATTACC
TTAAACATTGCTTTGAGTCCGCGAAAGAAGACCTAGCGCAAGGCAATGTGGTTAATGGTGAAGACTTCTTGCGCGCCTTG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References