Detailed information of TA system TA059379

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2831..3365
• Replicon: plasmid p3PS14
• Accession: NZ_CP013824
• Organism: Piscirickettsia salmonis strain PM25344B

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AVM71_RS17265
• Protein ID: WP_048876199.1
• Coordinates: 3075..3365 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1L6TI86
• Locus tag: AVM71_RS17260
• Protein ID: WP_027243211.1
• Coordinates: 2831..3085 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AVM71_RS17245 (AVM71_16850)	1..979	-	979	Protein_0	IS5 family transposase	-
AVM71_RS22115	1148..1441	+	294	WP_230382694.1	hypothetical protein	-
AVM71_RS17255 (AVM71_16860)	1460..2437	+	978	WP_036771347.1	IS5 family transposase	-
AVM71_RS19895	2452..2613	+	162	WP_155046636.1	hypothetical protein	-
AVM71_RS17260 (AVM71_16865)	2831..3085	+	255	WP_027243211.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
AVM71_RS17265 (AVM71_16870)	3075..3365	+	291	WP_048876199.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AVM71_RS17270 (AVM71_16875)	3352..4329	-	978	WP_036771347.1	IS5 family transposase	-
AVM71_RS17275 (AVM71_16880)	4601..5218	-	618	WP_230383014.1	Mov34/MPN/PAD-1 family protein	-
AVM71_RS17280 (AVM71_16885)	5335..5547	+	213	WP_053093683.1	hypothetical protein	-
AVM71_RS17285 (AVM71_16890)	5706..6683	+	978	WP_036771347.1	IS5 family transposase	-
AVM71_RS17290 (AVM71_16895)	6698..7144	+	447	WP_082304481.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..181103	181103

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-78)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-55)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11119.33 Da
• Isoelectric Point: 10.5762

>T59379 WP_048876199.1 NZ_CP013824:3075-3365 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLARR
CCVTSGPIFQAQFSCV

Nucleotide

• Length: 291 bp

>T59379 NZ_CP013824:3075-3365 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCAGGCGT
TGTTGCGTAACCTCTGGTCCCATATTCCAGGCACAATTCAGCTGCGTCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9554.83 Da
• Isoelectric Point: 4.3176

>AT59379 WP_027243211.1 NZ_CP013824:2831-3085 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Nucleotide

• Length: 255 bp

>AT59379 NZ_CP013824:2831-3085 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A1L6TI86