Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 141634..142277 Replicon plasmid p4PS10
Accession NZ_CP013820
Organism Piscirickettsia salmonis strain AY3800B

Toxin (Protein)


Gene name vapC Uniprot ID A0A1L6TI66
Locus tag AVM72_RS17390 Protein ID WP_027242931.1
Coordinates 141870..142277 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L6TI10
Locus tag AVM72_RS17385 Protein ID WP_027242932.1
Coordinates 141634..141861 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVM72_RS17360 137482..137889 - 408 WP_036817201.1 AAA family ATPase -
AVM72_RS17365 137997..139040 - 1044 WP_017375960.1 NAD(P)-dependent alcohol dehydrogenase -
AVM72_RS17370 139342..139575 + 234 WP_017375959.1 type II toxin-antitoxin system RelE/ParE family toxin -
AVM72_RS20435 139713..139862 - 150 WP_196214251.1 hypothetical protein -
AVM72_RS17375 139928..140257 + 330 WP_162038692.1 HigA family addiction module antidote protein -
AVM72_RS17380 141136..141501 + 366 WP_026063496.1 hypothetical protein -
AVM72_RS17385 141634..141861 + 228 WP_027242932.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AVM72_RS17390 141870..142277 + 408 WP_027242931.1 DUF4411 family protein Toxin
AVM72_RS17395 142423..143805 + 1383 WP_027242930.1 hypothetical protein -
AVM72_RS20440 143995..144198 + 204 WP_017375952.1 hypothetical protein -
AVM72_RS17400 144394..144777 + 384 WP_027242929.1 HNH endonuclease -
AVM72_RS17405 144864..145346 + 483 WP_075278733.1 P27 family phage terminase small subunit -
AVM72_RS17410 145349..146680 + 1332 WP_048876205.1 terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..188301 188301


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(7-41)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15562.93 Da        Isoelectric Point: 7.4168

>T59376 WP_027242931.1 NZ_CP013820:141870-142277 [Piscirickettsia salmonis]
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLDVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVDHLELEDWAS

Download         Length: 408 bp

>T59376 NZ_CP013820:141870-142277 [Piscirickettsia salmonis]
ATGCTTTATATGCTGGATACGAATATTTGTATTTATTTAATTAAACAAAAACCTCGCTCTTACTATGAGCGTTTGATGGA
GGTAGAAAAATCTCGTCATATATTGGCGATTTCATCGATTGTTTTATCTGAATTACAGTTTGGAGTGGCTCGCAGTCAAC
ACCAGCGAAAAAATCAGGAAGCAATTAATACCTTGGTGAATAAGCTCGATGTTTTACCCTATGAGGAAAAGGCAGCTAAA
TACTATGGTGACTTAAGGGCTGACTTACAAAAAAAAGGGACTGTGATTGGTGGGAATGATATGATCATAGCCGCACATGC
GCTTTCAGAAAAGGCTGTTTTAGTAACGCATAATACAAAAGAGTTTCAGCGTGTCGATCATTTAGAGCTTGAAGACTGGG
CAAGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8948.07 Da        Isoelectric Point: 4.5700

>AT59376 WP_027242932.1 NZ_CP013820:141634-141861 [Piscirickettsia salmonis]
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDRQDIQAQERDWF

Download         Length: 228 bp

>AT59376 NZ_CP013820:141634-141861 [Piscirickettsia salmonis]
ATGGCAAAATCACGAATTTTTAAAAGTGGTAATTCTCAAGCCGTTCGATTACCGAAAGAAATGCGCCTTGATGGTGAAGA
AGTGGTTATTCATCGGTTTGGCAACTCTTTATTAATCCAGCCAGTTTATGAAACCTGGATGGATGTTTACAATCATATGC
CGGATGTATCGGATGATTTTATGGAGGATCGCCAAGATATACAAGCACAAGAACGTGACTGGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6TI66

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI10

References