Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 39856..40499 Replicon plasmid p1PS12
Accession NZ_CP013807
Organism Piscirickettsia salmonis strain PM31429B

Toxin (Protein)


Gene name vapC Uniprot ID A0A1L6TI66
Locus tag AVM74_RS16500 Protein ID WP_027242931.1
Coordinates 39856..40263 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L6TI10
Locus tag AVM74_RS16505 Protein ID WP_027242932.1
Coordinates 40272..40499 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVM74_RS16480 35453..36784 - 1332 WP_048876205.1 terminase large subunit -
AVM74_RS16485 36787..37269 - 483 WP_081377963.1 P27 family phage terminase small subunit -
AVM74_RS16490 37356..37739 - 384 WP_027242929.1 HNH endonuclease -
AVM74_RS19755 37935..38138 - 204 WP_017375952.1 hypothetical protein -
AVM74_RS16495 38328..39710 - 1383 WP_027242930.1 hypothetical protein -
AVM74_RS16500 39856..40263 - 408 WP_027242931.1 DUF4411 family protein Toxin
AVM74_RS16505 40272..40499 - 228 WP_027242932.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AVM74_RS16510 40632..40997 - 366 WP_026063496.1 hypothetical protein -
AVM74_RS16515 41876..42205 - 330 WP_162038692.1 HigA family addiction module antidote protein -
AVM74_RS19760 42271..42420 + 150 WP_196214251.1 hypothetical protein -
AVM74_RS16525 42558..42791 - 234 WP_017375959.1 type II toxin-antitoxin system RelE/ParE family toxin -
AVM74_RS16530 43093..44136 + 1044 WP_017375960.1 NAD(P)-dependent alcohol dehydrogenase -
AVM74_RS16535 44244..44651 + 408 WP_036817201.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..181234 181234


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(7-41)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15562.93 Da        Isoelectric Point: 7.4168

>T59362 WP_027242931.1 NZ_CP013807:c40263-39856 [Piscirickettsia salmonis]
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLDVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVDHLELEDWAS

Download         Length: 408 bp

>T59362 NZ_CP013807:c40263-39856 [Piscirickettsia salmonis]
ATGCTTTATATGCTGGATACGAATATTTGTATTTATTTAATTAAACAAAAACCTCGCTCTTACTATGAGCGTTTGATGGA
GGTAGAAAAATCTCGTCATATATTGGCGATTTCATCGATTGTTTTATCTGAATTACAGTTTGGAGTGGCTCGCAGTCAAC
ACCAGCGAAAAAATCAGGAAGCAATTAATACCTTGGTGAATAAGCTCGATGTTTTACCCTATGAGGAAAAGGCAGCTAAA
TACTATGGTGACTTAAGGGCTGACTTACAAAAAAAAGGGACTGTGATTGGTGGGAATGATATGATCATAGCCGCACATGC
GCTTTCAGAAAAGGCTGTTTTAGTAACGCATAATACAAAAGAGTTTCAGCGTGTCGATCATTTAGAGCTTGAAGACTGGG
CAAGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8948.07 Da        Isoelectric Point: 4.5700

>AT59362 WP_027242932.1 NZ_CP013807:c40499-40272 [Piscirickettsia salmonis]
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDRQDIQAQERDWF

Download         Length: 228 bp

>AT59362 NZ_CP013807:c40499-40272 [Piscirickettsia salmonis]
ATGGCAAAATCACGAATTTTTAAAAGTGGTAATTCTCAAGCCGTTCGATTACCGAAAGAAATGCGCCTTGATGGTGAAGA
AGTGGTTATTCATCGGTTTGGCAACTCTTTATTAATCCAGCCAGTTTATGAAACCTGGATGGATGTTTACAATCATATGC
CGGATGTATCGGATGATTTTATGGAGGATCGCCAAGATATACAAGCACAAGAACGTGACTGGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6TI66

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI10

References