Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 161439..161970 Replicon plasmid p1PS9
Accession NZ_CP013797
Organism Piscirickettsia salmonis strain AY6532B

Toxin (Protein)


Gene name relE Uniprot ID A0A7U4YYE1
Locus tag AVI56_RS17330 Protein ID WP_027243212.1
Coordinates 161683..161970 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6TI86
Locus tag AVI56_RS17325 Protein ID WP_027243211.1
Coordinates 161439..161693 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVI56_RS17295 156525..156887 + 363 WP_027242596.1 hypothetical protein -
AVI56_RS17300 156927..157436 + 510 WP_027242595.1 hypothetical protein -
AVI56_RS17305 157668..158648 + 981 WP_144420849.1 hypothetical protein -
AVI56_RS17310 158730..159074 - 345 Protein_204 DDE-type integrase/transposase/recombinase -
AVI56_RS17315 159114..159986 - 873 WP_069971702.1 IS5 family transposase -
AVI56_RS17320 160068..161045 + 978 WP_036771347.1 IS5 family transposase -
AVI56_RS19835 161060..161221 + 162 WP_155046636.1 hypothetical protein -
AVI56_RS17325 161439..161693 + 255 WP_027243211.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AVI56_RS17330 161683..161970 + 288 WP_027243212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AVI56_RS17335 161977..162438 - 462 Protein_210 tail assembly protein -
AVI56_RS17340 162465..163292 - 828 WP_069971703.1 IS5 family transposase -
AVI56_RS17345 163296..164273 - 978 WP_036771347.1 IS5 family transposase -
AVI56_RS17350 164381..164872 - 492 WP_069971704.1 DUF1561 family protein -
AVI56_RS17355 164954..165931 + 978 WP_036771347.1 IS5 family transposase -
AVI56_RS17360 166059..166787 - 729 WP_036771359.1 IS6 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..188297 188297


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11063.21 Da        Isoelectric Point: 10.8855

>T59351 WP_027243212.1 NZ_CP013797:161683-161970 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Download         Length: 288 bp

>T59351 NZ_CP013797:161683-161970 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9554.83 Da        Isoelectric Point: 4.3176

>AT59351 WP_027243211.1 NZ_CP013797:161439-161693 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Download         Length: 255 bp

>AT59351 NZ_CP013797:161439-161693 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4YYE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI86

References