Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 19662..20193 Replicon plasmid p1PS7
Accession NZ_CP013787
Organism Piscirickettsia salmonis strain PM58386B

Toxin (Protein)


Gene name relE Uniprot ID A0A7U4YYE1
Locus tag AVI54_RS16385 Protein ID WP_027243212.1
Coordinates 19662..19949 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1L6TI86
Locus tag AVI54_RS16390 Protein ID WP_027243211.1
Coordinates 19939..20193 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVI54_RS16360 15842..16819 - 978 WP_036771347.1 IS5 family transposase -
AVI54_RS16365 16977..17189 - 213 WP_053093683.1 hypothetical protein -
AVI54_RS19715 17278..17394 + 117 Protein_22 phage minor tail protein L -
AVI54_RS16370 17363..17857 + 495 Protein_23 hypothetical protein -
AVI54_RS16375 18190..19167 + 978 WP_036771347.1 IS5 family transposase -
AVI54_RS16380 19194..19655 + 462 Protein_25 tail assembly protein -
AVI54_RS16385 19662..19949 - 288 WP_027243212.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AVI54_RS16390 19939..20193 - 255 WP_027243211.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AVI54_RS19720 20411..20572 - 162 WP_155046636.1 hypothetical protein -
AVI54_RS16395 20587..21564 - 978 WP_036771347.1 IS5 family transposase -
AVI54_RS16400 21661..21849 - 189 Protein_30 hypothetical protein -
AVI54_RS16405 22045..23022 + 978 WP_036771347.1 IS5 family transposase -
AVI54_RS16410 23062..23406 + 345 Protein_32 DDE-type integrase/transposase/recombinase -
AVI54_RS16415 23488..24468 - 981 WP_144420849.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..181332 181332


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-55)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11063.21 Da        Isoelectric Point: 10.8855

>T59337 WP_027243212.1 NZ_CP013787:c19949-19662 [Piscirickettsia salmonis]
MTYKLQFHKEAYKEWKKLNPTTQQQFQKVLKKRLINPHIPSAVCGGDLKGCYKIKLRALGYRLIYTVKKDKVVVQVLAIG
SRNRLEAYRLAASRL

Download         Length: 288 bp

>T59337 NZ_CP013787:c19949-19662 [Piscirickettsia salmonis]
ATGACTTATAAATTACAATTTCACAAAGAAGCGTATAAAGAGTGGAAAAAACTAAATCCAACAACTCAGCAACAGTTTCA
AAAAGTTTTGAAAAAACGCTTAATTAACCCACATATCCCATCAGCAGTGTGTGGTGGTGATTTAAAAGGCTGCTATAAAA
TTAAATTAAGAGCGCTCGGTTATCGTTTAATTTATACAGTGAAAAAGGACAAAGTGGTTGTTCAAGTCTTGGCCATTGGT
TCCAGAAACCGCTTAGAAGCGTATCGTTTAGCGGCAAGTCGCCTATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9554.83 Da        Isoelectric Point: 4.3176

>AT59337 WP_027243211.1 NZ_CP013787:c20193-19939 [Piscirickettsia salmonis]
MKQLYAQQSVTITELRKSPTSVINEANGEPVVILNHNVPAAYMVPPELFEAMLDSYEDRQLEGIVKKRLHSPDRDFIDVD
VDDL

Download         Length: 255 bp

>AT59337 NZ_CP013787:c20193-19939 [Piscirickettsia salmonis]
ATGAAACAGCTCTACGCACAACAGTCGGTAACAATTACAGAACTTAGAAAAAGCCCAACCAGCGTTATCAATGAAGCCAA
CGGCGAACCGGTGGTTATTTTGAATCATAATGTTCCTGCGGCGTACATGGTGCCACCTGAACTTTTTGAAGCCATGCTCG
ACTCGTATGAAGACCGCCAACTTGAAGGCATAGTCAAAAAACGTTTACATTCTCCTGACCGTGACTTTATTGATGTCGAT
GTCGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4YYE1

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI86

References