Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 39855..40498 Replicon plasmid p1PS6
Accession NZ_CP013782
Organism Piscirickettsia salmonis strain PM49811B

Toxin (Protein)


Gene name vapC Uniprot ID A0A1L6TI66
Locus tag AVI53_RS16530 Protein ID WP_027242931.1
Coordinates 39855..40262 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1L6TI10
Locus tag AVI53_RS16535 Protein ID WP_027242932.1
Coordinates 40271..40498 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVI53_RS16510 35452..36783 - 1332 WP_048876205.1 terminase large subunit -
AVI53_RS16515 36786..37268 - 483 WP_075278733.1 P27 family phage terminase small subunit -
AVI53_RS16520 37355..37738 - 384 WP_027242929.1 HNH endonuclease -
AVI53_RS19815 37934..38137 - 204 WP_017375952.1 hypothetical protein -
AVI53_RS16525 38327..39709 - 1383 WP_027242930.1 hypothetical protein -
AVI53_RS16530 39855..40262 - 408 WP_027242931.1 DUF4411 family protein Toxin
AVI53_RS16535 40271..40498 - 228 WP_027242932.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AVI53_RS16540 40631..40996 - 366 WP_026063496.1 hypothetical protein -
AVI53_RS16545 41875..42204 - 330 WP_162038692.1 HigA family addiction module antidote protein -
AVI53_RS19820 42270..42419 + 150 WP_196214251.1 hypothetical protein -
AVI53_RS16555 42557..42790 - 234 WP_017375959.1 type II toxin-antitoxin system RelE/ParE family toxin -
AVI53_RS16560 43092..44135 + 1044 WP_017375960.1 NAD(P)-dependent alcohol dehydrogenase -
AVI53_RS16565 44243..44650 + 408 WP_036817201.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..181226 181226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin

SpoVT-AbrB domain

(7-41)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15562.93 Da        Isoelectric Point: 7.4168

>T59332 WP_027242931.1 NZ_CP013782:c40262-39855 [Piscirickettsia salmonis]
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLDVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVDHLELEDWAS

Download         Length: 408 bp

>T59332 NZ_CP013782:c40262-39855 [Piscirickettsia salmonis]
ATGCTTTATATGCTGGATACGAATATTTGTATTTATTTAATTAAACAAAAACCTCGCTCTTACTATGAGCGTTTGATGGA
GGTAGAAAAATCTCGTCATATATTGGCGATTTCATCGATTGTTTTATCTGAATTACAGTTTGGAGTGGCTCGCAGTCAAC
ACCAGCGAAAAAATCAGGAAGCAATTAATACCTTGGTGAATAAGCTCGATGTTTTACCCTATGAGGAAAAGGCAGCTAAA
TACTATGGTGACTTAAGGGCTGACTTACAAAAAAAAGGGACTGTGATTGGTGGGAATGATATGATCATAGCCGCACATGC
GCTTTCAGAAAAGGCTGTTTTAGTAACGCATAATACAAAAGAGTTTCAGCGTGTCGATCATTTAGAGCTTGAAGACTGGG
CAAGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8948.07 Da        Isoelectric Point: 4.5700

>AT59332 WP_027242932.1 NZ_CP013782:c40498-40271 [Piscirickettsia salmonis]
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDRQDIQAQERDWF

Download         Length: 228 bp

>AT59332 NZ_CP013782:c40498-40271 [Piscirickettsia salmonis]
ATGGCAAAATCACGAATTTTTAAAAGTGGTAATTCTCAAGCCGTTCGATTACCGAAAGAAATGCGCCTTGATGGTGAAGA
AGTGGTTATTCATCGGTTTGGCAACTCTTTATTAATCCAGCCAGTTTATGAAACCTGGATGGATGTTTACAATCATATGC
CGGATGTATCGGATGATTTTATGGAGGATCGCCAAGATATACAAGCACAAGAACGTGACTGGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L6TI66

Antitoxin

Source ID Structure
AlphaFold DB A0A1L6TI10

References