Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 56190..56833 | Replicon | plasmid p2PS5 |
| Accession | NZ_CP013780 | ||
| Organism | Piscirickettsia salmonis strain PM51819A | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | E9LHC6 |
| Locus tag | AVI52_RS17820 | Protein ID | WP_016210974.1 |
| Coordinates | 56190..56597 (-) | Length | 136 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | E9LHC5 |
| Locus tag | AVI52_RS17825 | Protein ID | WP_016210972.1 |
| Coordinates | 56606..56833 (-) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AVI52_RS18885 | 51949..52266 | - | 318 | WP_164997282.1 | hypothetical protein | - |
| AVI52_RS18890 | 52321..52530 | - | 210 | WP_016212231.1 | hypothetical protein | - |
| AVI52_RS17790 | 52534..53013 | - | 480 | WP_016212234.1 | P27 family phage terminase small subunit | - |
| AVI52_RS17795 | 53101..53484 | - | 384 | WP_032126134.1 | HNH endonuclease | - |
| AVI52_RS17800 | 53785..54150 | - | 366 | WP_016212235.1 | hypothetical protein | - |
| AVI52_RS19855 | 54197..54376 | + | 180 | WP_155046773.1 | phosphatase | - |
| AVI52_RS19860 | 54521..54703 | + | 183 | WP_129556724.1 | hypothetical protein | - |
| AVI52_RS17810 | 54921..55214 | - | 294 | WP_016210977.1 | zinc ribbon domain-containing protein | - |
| AVI52_RS17815 | 55393..56073 | - | 681 | WP_129556725.1 | DNA/RNA non-specific endonuclease | - |
| AVI52_RS17820 | 56190..56597 | - | 408 | WP_016210974.1 | DUF4411 family protein | Toxin |
| AVI52_RS17825 | 56606..56833 | - | 228 | WP_016210972.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| AVI52_RS17830 | 56981..57373 | - | 393 | WP_129556726.1 | hypothetical protein | - |
| AVI52_RS17835 | 57488..57961 | - | 474 | WP_016210960.1 | single-stranded DNA-binding protein | - |
| AVI52_RS17840 | 57963..58247 | - | 285 | WP_036794070.1 | hypothetical protein | - |
| AVI52_RS17845 | 58244..58531 | - | 288 | WP_036794065.1 | hypothetical protein | - |
| AVI52_RS17850 | 58627..58866 | - | 240 | WP_016210963.1 | hypothetical protein | - |
| AVI52_RS17855 | 58863..59210 | - | 348 | WP_016210966.1 | hypothetical protein | - |
| AVI52_RS17860 | 59203..59565 | - | 363 | WP_016210959.1 | hypothetical protein | - |
| AVI52_RS17865 | 59534..60094 | - | 561 | WP_016210973.1 | hypothetical protein | - |
| AVI52_RS17870 | 60117..60932 | - | 816 | WP_016210962.1 | hypothetical protein | - |
| AVI52_RS17875 | 60979..61278 | - | 300 | WP_016210976.1 | hypothetical protein | - |
| AVI52_RS17880 | 61432..61737 | - | 306 | WP_016210958.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..122750 | 122750 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 15625.00 Da Isoelectric Point: 7.4170
>T59328 WP_016210974.1 NZ_CP013780:c56597-56190 [Piscirickettsia salmonis]
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLEVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVEHLEFEDWAS
MLYMLDTNICIYLIKQKPRSYYERLMEVEKSRHILAISSIVLSELQFGVARSQHQRKNQEAINTLVNKLEVLPYEEKAAK
YYGDLRADLQKKGTVIGGNDMIIAAHALSEKAVLVTHNTKEFQRVEHLEFEDWAS
Download Length: 408 bp
>T59328 NZ_CP013780:c56597-56190 [Piscirickettsia salmonis]
ATGCTTTATATGCTGGATACGAATATTTGTATTTATTTAATTAAACAAAAGCCTCGTTCTTACTATGAGCGTTTGATGGA
GGTAGAAAAATCTCGTCATATATTGGCGATTTCATCCATTGTTTTATCTGAATTACAGTTTGGAGTGGCTCGGAGTCAAC
ACCAGCGAAAAAACCAGGAAGCGATTAATACCTTGGTAAATAAGCTAGAAGTTTTACCCTATGAGGAAAAGGCAGCTAAA
TACTATGGTGACTTAAGGGCTGACTTACAAAAAAAAGGGACTGTGATTGGTGGGAATGATATGATCATAGCCGCGCATGC
GCTCTCAGAAAAAGCCGTTTTAGTGACACATAATACAAAAGAGTTTCAGCGTGTCGAGCATTTAGAGTTTGAAGACTGGG
CAAGTTAA
ATGCTTTATATGCTGGATACGAATATTTGTATTTATTTAATTAAACAAAAGCCTCGTTCTTACTATGAGCGTTTGATGGA
GGTAGAAAAATCTCGTCATATATTGGCGATTTCATCCATTGTTTTATCTGAATTACAGTTTGGAGTGGCTCGGAGTCAAC
ACCAGCGAAAAAACCAGGAAGCGATTAATACCTTGGTAAATAAGCTAGAAGTTTTACCCTATGAGGAAAAGGCAGCTAAA
TACTATGGTGACTTAAGGGCTGACTTACAAAAAAAAGGGACTGTGATTGGTGGGAATGATATGATCATAGCCGCGCATGC
GCTCTCAGAAAAAGCCGTTTTAGTGACACATAATACAAAAGAGTTTCAGCGTGTCGAGCATTTAGAGTTTGAAGACTGGG
CAAGTTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8929.02 Da Isoelectric Point: 4.5679
>AT59328 WP_016210972.1 NZ_CP013780:c56833-56606 [Piscirickettsia salmonis]
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDHQDIQAQERDWF
MAKSRIFKSGNSQAVRLPKEMRLDGEEVVIHRFGNSLLIQPVYETWMDVYNHMPDVSDDFMEDHQDIQAQERDWF
Download Length: 228 bp
>AT59328 NZ_CP013780:c56833-56606 [Piscirickettsia salmonis]
ATGGCAAAATCACGAATTTTTAAAAGTGGTAATTCCCAAGCCGTTCGGTTACCGAAAGAAATGCGGCTGGATGGTGAAGA
AGTGGTTATTCATCGGTTTGGCAACTCTTTATTAATCCAGCCAGTTTATGAAACCTGGATGGATGTTTACAATCATATGC
CGGATGTATCGGATGATTTTATGGAAGATCATCAAGATATACAAGCACAAGAACGTGACTGGTTTTAG
ATGGCAAAATCACGAATTTTTAAAAGTGGTAATTCCCAAGCCGTTCGGTTACCGAAAGAAATGCGGCTGGATGGTGAAGA
AGTGGTTATTCATCGGTTTGGCAACTCTTTATTAATCCAGCCAGTTTATGAAACCTGGATGGATGTTTACAATCATATGC
CGGATGTATCGGATGATTTTATGGAAGATCATCAAGATATACAAGCACAAGAACGTGACTGGTTTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|