Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 53328..53898 Replicon plasmid p1PS5
Accession NZ_CP013779
Organism Piscirickettsia salmonis strain PM51819A

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag AVI52_RS16665 Protein ID WP_129556708.1
Coordinates 53563..53898 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag AVI52_RS16660 Protein ID WP_016212365.1
Coordinates 53328..53570 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVI52_RS16640 48813..50498 - 1686 WP_075275141.1 protein kinase -
AVI52_RS16645 50781..51509 - 729 WP_075275142.1 IS6 family transposase -
AVI52_RS16650 51577..52017 - 441 Protein_73 tyrosine-type recombinase/integrase -
AVI52_RS16655 52145..53119 - 975 WP_054300271.1 IS30 family transposase -
AVI52_RS16660 53328..53570 + 243 WP_016212365.1 antidote-toxin recognition MazE family protein Antitoxin
AVI52_RS16665 53563..53898 + 336 WP_129556708.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AVI52_RS16670 54014..54742 + 729 WP_054300202.1 IS6 family transposase -
AVI52_RS16675 55212..55595 + 384 WP_016212152.1 hypothetical protein -
AVI52_RS16680 55902..56279 - 378 WP_016212154.1 DDE-type integrase/transposase/recombinase -
AVI52_RS16685 56443..56775 - 333 WP_032126739.1 transposase -
AVI52_RS16695 56964..57743 - 780 WP_081377351.1 transposase -
AVI52_RS16700 57844..58221 - 378 Protein_82 DDE-type integrase/transposase/recombinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..165427 165427
- inside IScluster/Tn - - 47073..80308 33235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-107)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12345.36 Da        Isoelectric Point: 10.3188

>T59326 WP_129556708.1 NZ_CP013779:53563-53898 [Piscirickettsia salmonis]
MNKVPERGDIIFLSLDPTLGSEQRGNRPFLVLTSKPYNLKVGLVTGCPVTSKIKGYPFEVEIPKNNSVHGAVLVNQLTTK
DFRARGWNHADKLDKKSLERVQGLIDVMLKG

Download         Length: 336 bp

>T59326 NZ_CP013779:53563-53898 [Piscirickettsia salmonis]
TTGAATAAAGTGCCTGAACGTGGTGATATTATTTTTCTTAGTTTAGACCCTACATTAGGTAGTGAACAAAGAGGAAACCG
ACCCTTTTTAGTGTTGACTTCCAAGCCCTATAACTTAAAGGTGGGACTTGTGACGGGGTGCCCGGTTACTTCAAAGATTA
AAGGATATCCTTTTGAAGTTGAGATACCTAAAAACAATAGCGTTCACGGAGCAGTGTTGGTTAACCAACTAACAACAAAA
GATTTCCGTGCTAGGGGCTGGAATCATGCTGATAAGCTCGATAAAAAATCTCTTGAAAGAGTTCAGGGGCTAATTGATGT
GATGTTGAAAGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.09 Da        Isoelectric Point: 4.4750

>AT59326 WP_016212365.1 NZ_CP013779:53328-53570 [Piscirickettsia salmonis]
MDAVVRKWGNSLGLLLPLSIARELHINDGSHVTIDKVGDEIHIKPLTHTQTLELLLSEITPENSHDLVDWGEELGGERFE

Download         Length: 243 bp

>AT59326 NZ_CP013779:53328-53570 [Piscirickettsia salmonis]
ATGGATGCAGTTGTTAGAAAATGGGGGAATAGCTTGGGGTTGTTGCTACCCTTGAGCATCGCACGTGAACTTCATATCAA
TGATGGTAGTCATGTGACGATTGATAAGGTCGGGGATGAGATTCACATTAAACCTTTGACTCATACGCAGACCCTTGAAT
TATTATTATCAGAAATTACCCCTGAAAATAGTCATGATTTAGTAGATTGGGGTGAAGAATTAGGAGGGGAGCGCTTTGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References