Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 79607..80177 Replicon plasmid p1PS4
Accession NZ_CP013774
Organism Piscirickettsia salmonis strain PM37984A

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag AVI51_RS16140 Protein ID WP_036781349.1
Coordinates 79607..79933 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag AVI51_RS16145 Protein ID WP_016212365.1
Coordinates 79935..80177 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVI51_RS16105 75283..75660 + 378 Protein_105 DDE-type integrase/transposase/recombinase -
AVI51_RS16110 75761..76540 + 780 WP_081377351.1 transposase -
AVI51_RS16120 76729..77061 + 333 WP_032126739.1 transposase -
AVI51_RS16125 77226..77603 + 378 WP_016212154.1 DDE-type integrase/transposase/recombinase -
AVI51_RS16130 77910..78293 - 384 WP_016212152.1 hypothetical protein -
AVI51_RS16135 78763..79491 - 729 WP_075273842.1 IS6 family transposase -
AVI51_RS16140 79607..79933 - 327 WP_036781349.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AVI51_RS16145 79935..80177 - 243 WP_016212365.1 antidote-toxin recognition MazE family protein Antitoxin
AVI51_RS16150 80382..80822 + 441 Protein_113 tyrosine-type recombinase/integrase -
AVI51_RS16155 80890..81618 + 729 WP_075274745.1 IS6-like element ISPsa2 family transposase -
AVI51_RS16160 81901..83511 + 1611 WP_075274746.1 protein kinase -
AVI51_RS18740 83632..84363 + 732 WP_016212311.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..138636 138636
- inside IScluster/Tn - - 70275..85251 14976


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-104)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11971.89 Da        Isoelectric Point: 10.1733

>T59323 WP_036781349.1 NZ_CP013774:c79933-79607 [Piscirickettsia salmonis]
VPERGDIIFLSLDPTLGSEQRGNRPFLVLTSKPYNLKVGLVTGCPVTSKIKGYPFEVELPKNNSVHGAVLVNQLTTKDFR
ARGWNHADKLDKKSLERVQGLIDVMLKG

Download         Length: 327 bp

>T59323 NZ_CP013774:c79933-79607 [Piscirickettsia salmonis]
GTGCCTGAACGTGGTGATATTATTTTTCTTAGTTTAGACCCTACATTAGGTAGTGAACAAAGAGGAAACCGACCCTTTTT
AGTGTTGACTTCCAAGCCCTATAACTTAAAGGTGGGACTTGTGACGGGGTGCCCGGTTACTTCAAAGATTAAAGGATATC
CTTTTGAAGTTGAGCTACCTAAAAACAATAGCGTTCACGGAGCAGTGTTGGTTAACCAACTAACAACAAAAGATTTCCGT
GCTAGGGGCTGGAATCATGCTGATAAGCTCGATAAAAAATCTCTTGAAAGAGTTCAGGGGCTAATTGATGTGATGTTGAA
AGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.09 Da        Isoelectric Point: 4.4750

>AT59323 WP_016212365.1 NZ_CP013774:c80177-79935 [Piscirickettsia salmonis]
MDAVVRKWGNSLGLLLPLSIARELHINDGSHVTIDKVGDEIHIKPLTHTQTLELLLSEITPENSHDLVDWGEELGGERFE

Download         Length: 243 bp

>AT59323 NZ_CP013774:c80177-79935 [Piscirickettsia salmonis]
ATGGATGCAGTTGTTAGAAAATGGGGGAATAGCTTGGGGTTGTTGCTACCCTTGAGCATCGCACGTGAACTTCATATCAA
TGATGGTAGTCATGTGACGATTGATAAGGTCGGGGATGAGATTCACATTAAACCTTTGACTCATACGCAGACCCTTGAAT
TATTATTATCAGAAATTACCCCTGAAAATAGTCATGATTTAGTAGATTGGGGTGAAGAATTAGGAGGGGAGCGCTTTGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References