Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 141274..141844 Replicon plasmid p1PS3
Accession NZ_CP013769
Organism Piscirickettsia salmonis strain PM23019A

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag AVI50_RS16645 Protein ID WP_036781349.1
Coordinates 141274..141600 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag AVI50_RS16650 Protein ID WP_016212365.1
Coordinates 141602..141844 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVI50_RS16610 136950..137327 + 378 Protein_190 DDE-type integrase/transposase/recombinase -
AVI50_RS16615 137428..138207 + 780 WP_081377351.1 transposase -
AVI50_RS16625 138396..138728 + 333 WP_032126739.1 transposase -
AVI50_RS16630 138893..139270 + 378 WP_016212154.1 DDE-type integrase/transposase/recombinase -
AVI50_RS16635 139577..139960 - 384 WP_016212152.1 hypothetical protein -
AVI50_RS16640 140430..141158 - 729 WP_075273842.1 IS6 family transposase -
AVI50_RS16645 141274..141600 - 327 WP_036781349.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AVI50_RS16650 141602..141844 - 243 WP_016212365.1 antidote-toxin recognition MazE family protein Antitoxin
AVI50_RS16655 142049..142489 + 441 Protein_198 tyrosine-type recombinase/integrase -
AVI50_RS16660 142557..143285 + 729 WP_075274745.1 IS6-like element ISPsa2 family transposase -
AVI50_RS16665 143568..145202 + 1635 WP_075273844.1 protein kinase -
AVI50_RS19210 145323..146054 + 732 WP_016212311.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..153216 153216
- inside IScluster/Tn - - 131942..146942 15000


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-104)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11971.89 Da        Isoelectric Point: 10.1733

>T59319 WP_036781349.1 NZ_CP013769:c141600-141274 [Piscirickettsia salmonis]
VPERGDIIFLSLDPTLGSEQRGNRPFLVLTSKPYNLKVGLVTGCPVTSKIKGYPFEVELPKNNSVHGAVLVNQLTTKDFR
ARGWNHADKLDKKSLERVQGLIDVMLKG

Download         Length: 327 bp

>T59319 NZ_CP013769:c141600-141274 [Piscirickettsia salmonis]
GTGCCTGAACGTGGTGATATTATTTTTCTTAGTTTAGACCCTACATTAGGTAGTGAACAAAGAGGAAACCGACCCTTTTT
AGTGTTGACTTCCAAGCCCTATAACTTAAAGGTGGGACTTGTGACGGGGTGCCCGGTTACTTCAAAGATTAAAGGATATC
CTTTTGAAGTTGAGCTACCTAAAAACAATAGCGTTCACGGAGCAGTGTTGGTTAACCAACTAACAACAAAAGATTTCCGT
GCTAGGGGCTGGAATCATGCTGATAAGCTCGATAAAAAATCTCTTGAAAGAGTTCAGGGGCTAATTGATGTGATGTTGAA
AGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.09 Da        Isoelectric Point: 4.4750

>AT59319 WP_016212365.1 NZ_CP013769:c141844-141602 [Piscirickettsia salmonis]
MDAVVRKWGNSLGLLLPLSIARELHINDGSHVTIDKVGDEIHIKPLTHTQTLELLLSEITPENSHDLVDWGEELGGERFE

Download         Length: 243 bp

>AT59319 NZ_CP013769:c141844-141602 [Piscirickettsia salmonis]
ATGGATGCAGTTGTTAGAAAATGGGGGAATAGCTTGGGGTTGTTGCTACCCTTGAGCATCGCACGTGAACTTCATATCAA
TGATGGTAGTCATGTGACGATTGATAAGGTCGGGGATGAGATTCACATTAAACCTTTGACTCATACGCAGACCCTTGAAT
TATTATTATCAGAAATTACCCCTGAAAATAGTCATGATTTAGTAGATTGGGGTGAAGAATTAGGAGGGGAGCGCTTTGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References