Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 29945..30515 Replicon plasmid p1PS2
Accession NZ_CP013763
Organism Piscirickettsia salmonis strain PM21567A

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag AVI49_RS15735 Protein ID WP_036781349.1
Coordinates 30189..30515 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag AVI49_RS15730 Protein ID WP_016212365.1
Coordinates 29945..30187 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVI49_RS15705 25498..26229 - 732 WP_016212311.1 hypothetical protein -
AVI49_RS15710 26350..27933 - 1584 WP_052047129.1 protein kinase -
AVI49_RS15715 28216..28485 - 270 Protein_36 DDE-type integrase/transposase/recombinase -
AVI49_RS18735 28412..28591 + 180 WP_155047017.1 hypothetical protein -
AVI49_RS15720 28765..29232 - 468 Protein_38 IS6-like element ISPsa2 family transposase -
AVI49_RS15725 29300..29740 - 441 Protein_39 tyrosine-type recombinase/integrase -
AVI49_RS15730 29945..30187 + 243 WP_016212365.1 antidote-toxin recognition MazE family protein Antitoxin
AVI49_RS15735 30189..30515 + 327 WP_036781349.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AVI49_RS15740 30631..31359 + 729 WP_075273842.1 IS6 family transposase -
AVI49_RS15745 31829..32212 + 384 WP_016212152.1 hypothetical protein -
AVI49_RS15750 32519..32896 - 378 WP_016212154.1 DDE-type integrase/transposase/recombinase -
AVI49_RS15755 33061..33393 - 333 WP_032126739.1 transposase -
AVI49_RS15765 33582..34361 - 780 WP_081377351.1 transposase -
AVI49_RS15770 34462..34839 - 378 Protein_47 DDE-type integrase/transposase/recombinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..120730 120730
- inside IScluster/Tn - - 24610..39847 15237


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-104)

Antitoxin

Antitoxin PemI-like

(1-77)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11971.89 Da        Isoelectric Point: 10.1733

>T59313 WP_036781349.1 NZ_CP013763:30189-30515 [Piscirickettsia salmonis]
VPERGDIIFLSLDPTLGSEQRGNRPFLVLTSKPYNLKVGLVTGCPVTSKIKGYPFEVELPKNNSVHGAVLVNQLTTKDFR
ARGWNHADKLDKKSLERVQGLIDVMLKG

Download         Length: 327 bp

>T59313 NZ_CP013763:30189-30515 [Piscirickettsia salmonis]
GTGCCTGAACGTGGTGATATTATTTTTCTTAGTTTAGACCCTACATTAGGTAGTGAACAAAGAGGAAACCGACCCTTTTT
AGTGTTGACTTCCAAGCCCTATAACTTAAAGGTGGGACTTGTGACGGGGTGCCCGGTTACTTCAAAGATTAAAGGATATC
CTTTTGAAGTTGAGCTACCTAAAAACAATAGCGTTCACGGAGCAGTGTTGGTTAACCAACTAACAACAAAAGATTTCCGT
GCTAGGGGCTGGAATCATGCTGATAAGCTCGATAAAAAATCTCTTGAAAGAGTTCAGGGGCTAATTGATGTGATGTTGAA
AGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.09 Da        Isoelectric Point: 4.4750

>AT59313 WP_016212365.1 NZ_CP013763:29945-30187 [Piscirickettsia salmonis]
MDAVVRKWGNSLGLLLPLSIARELHINDGSHVTIDKVGDEIHIKPLTHTQTLELLLSEITPENSHDLVDWGEELGGERFE

Download         Length: 243 bp

>AT59313 NZ_CP013763:29945-30187 [Piscirickettsia salmonis]
ATGGATGCAGTTGTTAGAAAATGGGGGAATAGCTTGGGGTTGTTGCTACCCTTGAGCATCGCACGTGAACTTCATATCAA
TGATGGTAGTCATGTGACGATTGATAAGGTCGGGGATGAGATTCACATTAAACCTTTGACTCATACGCAGACCCTTGAAT
TATTATTATCAGAAATTACCCCTGAAAATAGTCATGATTTAGTAGATTGGGGTGAAGAATTAGGAGGGGAGCGCTTTGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References