Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1137661..1138187 Replicon chromosome
Accession NZ_CP013747
Organism Pseudarthrobacter sulfonivorans strain Ar51

Toxin (Protein)


Gene name mazF Uniprot ID A0A0U3R5X9
Locus tag AU252_RS05015 Protein ID WP_058929779.1
Coordinates 1137661..1137987 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0U2X9F4
Locus tag AU252_RS05020 Protein ID WP_058929780.1
Coordinates 1137984..1138187 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AU252_RS23760 1135048..1136865 - 1818 WP_157768930.1 S8 family serine peptidase -
AU252_RS23565 1137053..1137524 + 472 Protein_988 alkaline phosphatase D family protein -
AU252_RS05015 1137661..1137987 - 327 WP_058929779.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AU252_RS05020 1137984..1138187 - 204 WP_058929780.1 DUF3018 family protein Antitoxin
AU252_RS05025 1138405..1139118 + 714 WP_157768931.1 hypothetical protein -
AU252_RS05030 1139121..1139696 + 576 WP_058929782.1 hypothetical protein -
AU252_RS05035 1139784..1141022 - 1239 WP_058929783.1 S8 family serine peptidase -
AU252_RS05040 1141200..1141925 + 726 WP_058929784.1 hemerythrin domain-containing protein -
AU252_RS23045 1142233..1143120 - 888 WP_083510268.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(4-65)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11668.59 Da        Isoelectric Point: 10.7342

>T59308 WP_058929779.1 NZ_CP013747:c1137987-1137661 [Pseudarthrobacter sulfonivorans]
VNRGELWTVSGGTDAQKPRPALIIQDDLFAASKSITLLPLTSQLTDAPLLRLTVEPGQLTGLERVSQIMVDKLTTVRRAN
VGQRMGRVDAKTMVAVEQSLAVFLGLGR

Download         Length: 327 bp

>T59308 NZ_CP013747:c1137987-1137661 [Pseudarthrobacter sulfonivorans]
GTGAATCGAGGCGAGCTGTGGACGGTCTCAGGCGGAACAGATGCGCAAAAACCAAGGCCAGCACTGATCATCCAGGATGA
CCTTTTTGCGGCGTCAAAGTCGATCACCCTCCTGCCCTTGACGTCGCAACTGACGGACGCCCCACTGCTGAGGCTGACGG
TTGAACCCGGCCAACTCACTGGCCTGGAGCGCGTAAGTCAGATCATGGTGGACAAGCTGACCACGGTGCGTCGCGCCAAC
GTTGGCCAGCGAATGGGGCGAGTGGATGCCAAGACCATGGTCGCAGTCGAGCAGTCGTTGGCCGTCTTTCTTGGTCTGGG
ACGCTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7975.92 Da        Isoelectric Point: 5.8508

>AT59308 WP_058929780.1 NZ_CP013747:c1138187-1137984 [Pseudarthrobacter sulfonivorans]
MSVRDRVARHRLAMRERGFRQIQMWVPDARTEEFKREARRQAMAVAAADRAGDDQDFVEQISEDWPE

Download         Length: 204 bp

>AT59308 NZ_CP013747:c1138187-1137984 [Pseudarthrobacter sulfonivorans]
ATGAGCGTACGGGATCGCGTTGCACGCCACAGGCTCGCCATGCGCGAGCGTGGCTTCCGACAGATTCAAATGTGGGTGCC
GGACGCACGCACGGAGGAATTCAAGCGTGAAGCGCGCCGGCAAGCCATGGCAGTTGCCGCCGCAGACCGCGCCGGTGACG
ACCAGGATTTCGTTGAGCAAATTTCGGAAGACTGGCCGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U3R5X9

Antitoxin

Source ID Structure
AlphaFold DB A0A0U2X9F4

References