59288

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2375275..2375804 Replicon chromosome
Accession NZ_CP013741
Organism Mycobacterium tuberculosis variant bovis strain BCG-1 (Russia)

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag BOVR_RS11090 Protein ID WP_003411124.1
Coordinates 2375275..2375592 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag BOVR_RS11095 Protein ID WP_003411127.1
Coordinates 2375589..2375804 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOVR_RS11060 2370412..2371488 + 1077 WP_003411110.1 hypothetical protein -
BOVR_RS11065 2371485..2371766 + 282 WP_019283661.1 hypothetical protein -
BOVR_RS11070 2371802..2372875 + 1074 WP_011799246.1 quinone-dependent dihydroorotate dehydrogenase -
BOVR_RS11075 2372880..2373410 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
BOVR_RS11080 2373458..2374804 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
BOVR_RS11090 2375275..2375592 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BOVR_RS11095 2375589..2375804 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
BOVR_RS11100 2376059..2377117 + 1059 WP_003411129.1 hypothetical protein -
BOVR_RS11105 2377247..2377603 - 357 WP_003411130.1 hypothetical protein -
BOVR_RS11110 2377698..2378480 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
BOVR_RS11115 2378748..2379038 - 291 WP_003900476.1 YggT family protein -
BOVR_RS11120 2379200..2379856 - 657 WP_003411133.1 cell division protein SepF -
BOVR_RS11125 2379922..2380698 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T59288 WP_003411124.1 NZ_CP013741:c2375592-2375275 [Mycobacterium tuberculosis variant bovis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T59288 NZ_CP013741:c2375592-2375275 [Mycobacterium tuberculosis variant bovis]
ATGACGCGTAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT59288 WP_003411127.1 NZ_CP013741:c2375804-2375589 [Mycobacterium tuberculosis variant bovis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT59288 NZ_CP013741:c2375804-2375589 [Mycobacterium tuberculosis variant bovis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References