Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1946065..1946525 Replicon chromosome
Accession NZ_CP013741
Organism Mycobacterium tuberculosis variant bovis strain BCG-1 (Russia)

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag BOVR_RS09055 Protein ID WP_003408531.1
Coordinates 1946277..1946525 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag BOVR_RS09050 Protein ID WP_003408528.1
Coordinates 1946065..1946277 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOVR_RS09035 1942543..1943730 - 1188 WP_003898992.1 nitrate transporter NarK -
BOVR_RS09040 1944017..1944301 + 285 WP_003408522.1 DUF1876 domain-containing protein -
BOVR_RS09045 1944315..1945997 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
BOVR_RS09050 1946065..1946277 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BOVR_RS09055 1946277..1946525 + 249 WP_003408531.1 hypothetical protein Toxin
BOVR_RS09060 1946533..1947271 + 739 Protein_1766 hypothetical protein -
BOVR_RS09065 1947365..1949065 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
BOVR_RS09070 1949350..1949751 - 402 WP_010950586.1 hypothetical protein -
BOVR_RS09075 1949822..1950352 - 531 WP_011799212.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T59277 WP_003408531.1 NZ_CP013741:1946277-1946525 [Mycobacterium tuberculosis variant bovis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T59277 NZ_CP013741:1946277-1946525 [Mycobacterium tuberculosis variant bovis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATACGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT59277 WP_003408528.1 NZ_CP013741:1946065-1946277 [Mycobacterium tuberculosis variant bovis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT59277 NZ_CP013741:1946065-1946277 [Mycobacterium tuberculosis variant bovis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References