59273

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1572085..1572740 Replicon chromosome
Accession NZ_CP013741
Organism Mycobacterium tuberculosis variant bovis strain BCG-1 (Russia)

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FAR1
Locus tag BOVR_RS07420 Protein ID WP_003407268.1
Coordinates 1572085..1572486 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag BOVR_RS07425 Protein ID WP_003407272.1
Coordinates 1572483..1572740 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOVR_RS07405 1567929..1569314 - 1386 WP_003407260.1 cytochrome P450 -
BOVR_RS07410 1569392..1570426 + 1035 WP_003407264.1 AraC family transcriptional regulator -
BOVR_RS07415 1570472..1571830 - 1359 WP_010950541.1 PE family protein -
BOVR_RS07420 1572085..1572486 - 402 WP_003407268.1 type II toxin-antitoxin system VapC family toxin Toxin
BOVR_RS07425 1572483..1572740 - 258 WP_003407272.1 ribbon-helix-helix domain-containing protein Antitoxin
BOVR_RS07430 1572823..1573782 - 960 WP_011799179.1 alpha/beta hydrolase -
BOVR_RS07435 1573807..1574769 - 963 WP_003407279.1 alpha/beta hydrolase -
BOVR_RS07440 1574768..1575505 + 738 WP_031647000.1 lysoplasmalogenase -
BOVR_RS07445 1575586..1577553 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14894.39 Da        Isoelectric Point: 11.6897

>T59273 WP_003407268.1 NZ_CP013741:c1572486-1572085 [Mycobacterium tuberculosis variant bovis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQGLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T59273 NZ_CP013741:c1572486-1572085 [Mycobacterium tuberculosis variant bovis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGGCCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT59273 WP_003407272.1 NZ_CP013741:c1572740-1572483 [Mycobacterium tuberculosis variant bovis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT59273 NZ_CP013741:c1572740-1572483 [Mycobacterium tuberculosis variant bovis]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FAR1

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References