Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 1242470..1243038 | Replicon | chromosome |
Accession | NZ_CP013741 | ||
Organism | Mycobacterium tuberculosis variant bovis strain BCG-1 (Russia) |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TH08 |
Locus tag | BOVR_RS05930 | Protein ID | WP_003405865.1 |
Coordinates | 1242664..1243038 (+) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TH07 |
Locus tag | BOVR_RS05925 | Protein ID | WP_003405863.1 |
Coordinates | 1242470..1242667 (+) | Length | 66 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BOVR_RS05905 | 1238511..1239149 | - | 639 | WP_011799158.1 | lipid droplet-associated protein | - |
BOVR_RS05910 | 1239239..1240246 | + | 1008 | WP_003405853.1 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | - |
BOVR_RS05915 | 1240263..1241246 | - | 984 | WP_003898731.1 | hypothetical protein | - |
BOVR_RS05920 | 1241309..1242382 | + | 1074 | WP_003405860.1 | redox-regulated ATPase YchF | - |
BOVR_RS05925 | 1242470..1242667 | + | 198 | WP_003405863.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
BOVR_RS05930 | 1242664..1243038 | + | 375 | WP_003405865.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
BOVR_RS05935 | 1243241..1243939 | + | 699 | WP_010950494.1 | hypothetical protein | - |
BOVR_RS05940 | 1244057..1244242 | + | 186 | WP_003901093.1 | hypothetical protein | - |
BOVR_RS05945 | 1244169..1244444 | - | 276 | WP_003405867.1 | hypothetical protein | - |
BOVR_RS05950 | 1244687..1245010 | + | 324 | WP_003405871.1 | antibiotic biosynthesis monooxygenase | - |
BOVR_RS05955 | 1245025..1245735 | - | 711 | WP_003911399.1 | hypothetical protein | - |
BOVR_RS22280 | 1245757..1245966 | + | 210 | WP_003911400.1 | hypothetical protein | - |
BOVR_RS05965 | 1245918..1246625 | - | 708 | Protein_1160 | adenylate/guanylate cyclase domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13444.56 Da Isoelectric Point: 5.1881
>T59269 WP_003405865.1 NZ_CP013741:1242664-1243038 [Mycobacterium tuberculosis variant bovis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS
Download Length: 375 bp
>T59269 NZ_CP013741:1242664-1243038 [Mycobacterium tuberculosis variant bovis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA
Antitoxin
Download Length: 66 a.a. Molecular weight: 6973.03 Da Isoelectric Point: 11.7327
>AT59269 WP_003405863.1 NZ_CP013741:1242470-1242667 [Mycobacterium tuberculosis variant bovis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR
Download Length: 198 bp
>AT59269 NZ_CP013741:1242470-1242667 [Mycobacterium tuberculosis variant bovis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|