Detailed information of TA system TA059265

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 1016795..1017414
• Replicon: chromosome
• Accession: NZ_CP013741
• Organism: Mycobacterium tuberculosis variant bovis strain BCG-1 (Russia)

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: BOVR_RS04805
• Protein ID: WP_003404726.1
• Coordinates: 1016980..1017414 (+)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: G0TFQ5
• Locus tag: BOVR_RS04800
• Protein ID: WP_003404724.1
• Coordinates: 1016795..1016974 (+)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BOVR_RS04790	1012268..1013848	+	1581	WP_011799139.1	serine hydrolase	-
BOVR_RS04795	1013845..1016238	+	2394	WP_003898639.1	cation-translocating P-type ATPase	-
BOVR_RS22245	1016511..1016669	+	159	WP_003404720.1	hypothetical protein	-
BOVR_RS04800	1016795..1016974	+	180	WP_003404724.1	antitoxin	Antitoxin
BOVR_RS04805	1016980..1017414	+	435	WP_003404726.1	SRPBCC family protein	Toxin
BOVR_RS04810	1017512..1018285	+	774	WP_003404735.1	VOC family protein	-
BOVR_RS04815	1018350..1018799	+	450	WP_003404738.1	hypothetical protein	-
BOVR_RS04820	1018934..1019164	-	231	WP_003898642.1	hypothetical protein	-
BOVR_RS04825	1019331..1020839	-	1509	WP_003404742.1	carotenoid oxygenase family protein	-
BOVR_RS04830	1020841..1022079	-	1239	WP_003404744.1	acetyl-CoA acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-50)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15754.47 Da
• Isoelectric Point: 9.7977

>T59265 WP_003404726.1 NZ_CP013741:1016980-1017414 [Mycobacterium tuberculosis variant bovis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Nucleotide

• Length: 435 bp

>T59265 NZ_CP013741:1016980-1017414 [Mycobacterium tuberculosis variant bovis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6394.06 Da
• Isoelectric Point: 4.3059

>AT59265 WP_003404724.1 NZ_CP013741:1016795-1016974 [Mycobacterium tuberculosis variant bovis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQDAASNVVGMSDQQS

Nucleotide

• Length: 180 bp

>AT59265 NZ_CP013741:1016795-1016974 [Mycobacterium tuberculosis variant bovis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCAGGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Structures

Antitoxin

• AlphaFold DB: G0TFQ5