Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3819333..3819967 Replicon chromosome
Accession NZ_CP013738
Organism Streptomyces globisporus C-1027

Toxin (Protein)


Gene name vapC Uniprot ID A0A0U3KJK9
Locus tag WQO_RS16565 Protein ID WP_010056558.1
Coordinates 3819545..3819967 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7Y6LTE2
Locus tag WQO_RS16560 Protein ID WP_010056557.1
Coordinates 3819333..3819548 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WQO_RS16540 3815140..3815694 - 555 WP_107115827.1 hypothetical protein -
WQO_RS16545 3815719..3816639 - 921 WP_032747500.1 hypothetical protein -
WQO_RS16550 3817426..3818028 - 603 WP_148660111.1 IS630 family transposase -
WQO_RS16555 3817953..3818492 - 540 WP_058953860.1 winged helix-turn-helix domain-containing protein -
WQO_RS16560 3819333..3819548 + 216 WP_010056557.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
WQO_RS16565 3819545..3819967 + 423 WP_010056558.1 PIN domain nuclease Toxin
WQO_RS16570 3820090..3821343 - 1254 WP_010056559.1 protein-glutamate O-methyltransferase family protein -
WQO_RS16575 3821340..3821606 - 267 WP_010056560.1 hypothetical protein -
WQO_RS16580 3821678..3822238 - 561 WP_010056562.1 hypothetical protein -
WQO_RS16585 3822402..3822986 + 585 WP_010056564.1 TetR/AcrR family transcriptional regulator -
WQO_RS16590 3823034..3823750 - 717 WP_010056565.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-49)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15526.38 Da        Isoelectric Point: 4.9090

>T59246 WP_010056558.1 NZ_CP013738:3819545-3819967 [Streptomyces globisporus C-1027]
VSAAQFLIDTSALARFFRNDAEQYGWDQAATAGLIATCPVTELEFFHSARSAEDRARGIEDMRLLFGWVPVDDRAYDRAW
QVQELLTRRGQHRSAGAVDLVVAATAELQGLTLLHRDHDFECIAAITGQAMQWYGPASGK

Download         Length: 423 bp

>T59246 NZ_CP013738:3819545-3819967 [Streptomyces globisporus C-1027]
GTGAGCGCGGCACAGTTCCTGATCGACACCAGCGCGCTCGCCCGGTTCTTCCGCAACGACGCCGAGCAGTACGGATGGGA
TCAGGCCGCCACGGCAGGGCTCATCGCGACCTGCCCCGTTACCGAGCTGGAGTTCTTCCACAGCGCCCGCTCCGCCGAGG
ACCGGGCGCGCGGCATCGAGGACATGCGGCTGCTGTTCGGCTGGGTGCCCGTCGATGACCGCGCGTACGACCGCGCCTGG
CAGGTTCAGGAGCTGCTGACCCGACGCGGCCAGCACCGCAGTGCGGGAGCTGTTGACCTCGTCGTTGCCGCCACAGCGGA
ACTCCAGGGGCTGACCCTCCTGCACCGCGACCATGACTTCGAATGTATCGCCGCGATCACCGGTCAGGCCATGCAGTGGT
ACGGCCCGGCGTCCGGTAAATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7963.97 Da        Isoelectric Point: 5.1070

>AT59246 WP_010056557.1 NZ_CP013738:3819333-3819548 [Streptomyces globisporus C-1027]
MSRTVIDLDDELLADVAQALGTGTKKETVNTALREVLDNRRRALALTRLRAAAGEGAFDLDVFEDKRDYRR

Download         Length: 216 bp

>AT59246 NZ_CP013738:3819333-3819548 [Streptomyces globisporus C-1027]
ATGAGTCGCACCGTGATCGATCTCGACGACGAGCTGCTGGCCGACGTGGCTCAGGCGCTGGGGACCGGCACCAAGAAGGA
GACGGTCAACACTGCTCTGCGCGAGGTGCTCGACAACCGCCGACGGGCTCTCGCTCTCACGCGGCTGCGGGCTGCAGCGG
GCGAGGGCGCGTTCGATCTGGATGTCTTCGAGGACAAGAGGGACTACCGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U3KJK9

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y6LTE2

References