Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2552141..2552705 Replicon chromosome
Accession NZ_CP013738
Organism Streptomyces globisporus C-1027

Toxin (Protein)


Gene name mazF Uniprot ID A0A0U3KC30
Locus tag WQO_RS11020 Protein ID WP_029182541.1
Coordinates 2552141..2552488 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0U3MAY3
Locus tag WQO_RS11025 Protein ID WP_029182542.1
Coordinates 2552481..2552705 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WQO_RS11010 2547474..2550782 + 3309 WP_193407179.1 S8 family serine peptidase -
WQO_RS11015 2551038..2552066 + 1029 WP_010063002.1 aspartate-semialdehyde dehydrogenase -
WQO_RS11020 2552141..2552488 - 348 WP_029182541.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
WQO_RS11025 2552481..2552705 - 225 WP_029182542.1 ribbon-helix-helix protein, CopG family Antitoxin
WQO_RS11030 2552760..2553260 - 501 WP_010063005.1 DUF1203 domain-containing protein -
WQO_RS11035 2553386..2555962 + 2577 WP_010063006.1 aminopeptidase N -
WQO_RS11040 2556167..2556715 + 549 WP_010063007.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-37)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12671.60 Da        Isoelectric Point: 11.5710

>T59245 WP_029182541.1 NZ_CP013738:c2552488-2552141 [Streptomyces globisporus C-1027]
MRRGDIHLVDLEPARGSEANKVRPAVIVSNNAANRSAEVSGRGVVAVVPLTSNTSRILSFQVLLTAEESRLPQNSKAQCE
QIRAVSPDRILKRLGEVPRQRMAEIDKALRRHLAL

Download         Length: 348 bp

>T59245 NZ_CP013738:c2552488-2552141 [Streptomyces globisporus C-1027]
ATGCGTAGGGGCGACATCCATCTCGTGGACCTGGAGCCCGCGCGGGGGAGCGAAGCCAACAAGGTGCGACCGGCGGTGAT
CGTCTCCAACAACGCCGCCAACCGGTCGGCCGAGGTGTCCGGCAGGGGCGTCGTCGCTGTGGTGCCCCTGACCTCGAACA
CCTCGCGGATCCTCAGCTTCCAGGTGCTTCTCACCGCGGAGGAGAGCCGCCTCCCGCAGAACTCCAAGGCCCAGTGCGAG
CAGATCCGGGCGGTCTCCCCCGACCGAATTCTGAAGCGCCTCGGTGAGGTGCCCCGTCAGCGCATGGCGGAGATCGACAA
GGCTCTGCGCCGCCACCTCGCCCTCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8047.76 Da        Isoelectric Point: 3.7610

>AT59245 WP_029182542.1 NZ_CP013738:c2552705-2552481 [Streptomyces globisporus C-1027]
MKISVSLPQEDVAFVDEYAAKTDADSRSAVIHAAIDLLRTAGLEAEYTEAFQEWDASEDAALWDRTVADGLTDA

Download         Length: 225 bp

>AT59245 NZ_CP013738:c2552705-2552481 [Streptomyces globisporus C-1027]
ATGAAGATTAGTGTGAGTCTGCCCCAGGAGGATGTCGCCTTCGTCGACGAGTACGCGGCGAAGACCGACGCCGATTCCCG
GTCCGCCGTCATACACGCCGCCATCGACTTGCTGCGCACCGCGGGACTGGAGGCGGAGTACACCGAGGCGTTCCAGGAGT
GGGACGCGAGTGAGGACGCCGCTCTGTGGGACCGCACGGTGGCCGACGGGCTCACGGATGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U3KC30

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3MAY3

References