Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2137218..2137818 Replicon chromosome
Accession NZ_CP013737
Organism Herbaspirillum rubrisubalbicans M1

Toxin (Protein)


Gene name hicA Uniprot ID A0A0U3LKM6
Locus tag HRUBRI_RS09355 Protein ID WP_058895169.1
Coordinates 2137636..2137818 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U3L9Y5
Locus tag HRUBRI_RS09350 Protein ID WP_058895168.1
Coordinates 2137218..2137616 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRUBRI_RS09325 2132954..2134594 + 1641 WP_058895166.1 Kef family K(+) transporter -
HRUBRI_RS09330 2134937..2135440 + 504 WP_017450864.1 6,7-dimethyl-8-ribityllumazine synthase -
HRUBRI_RS09335 2135622..2135948 + 327 WP_058895167.1 hypothetical protein -
HRUBRI_RS09340 2136072..2136632 - 561 WP_017450866.1 DUF2242 domain-containing protein -
HRUBRI_RS09345 2136912..2137133 + 222 WP_017450867.1 hypothetical protein -
HRUBRI_RS09350 2137218..2137616 - 399 WP_058895168.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HRUBRI_RS09355 2137636..2137818 - 183 WP_058895169.1 type II toxin-antitoxin system HicA family toxin Toxin
HRUBRI_RS24795 2138077..2138241 - 165 WP_156425821.1 hypothetical protein -
HRUBRI_RS09365 2138258..2139124 + 867 WP_058897533.1 alpha/beta hydrolase -
HRUBRI_RS09370 2139206..2139556 + 351 WP_008328017.1 RidA family protein -
HRUBRI_RS09375 2139563..2141815 + 2253 WP_017450871.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6725.89 Da        Isoelectric Point: 11.1923

>T59241 WP_058895169.1 NZ_CP013737:c2137818-2137636 [Herbaspirillum rubrisubalbicans M1]
MDSATLIQRLKANGWYLVHTVGSHHQFKHRTMPGKVTVPHPKKDLPLATQNSILKQAGLK

Download         Length: 183 bp

>T59241 NZ_CP013737:c2137818-2137636 [Herbaspirillum rubrisubalbicans M1]
ATGGACAGCGCAACCCTCATCCAACGACTCAAGGCCAACGGCTGGTACTTGGTGCATACAGTAGGTTCGCATCACCAGTT
CAAGCATCGAACCATGCCCGGCAAGGTCACAGTACCGCATCCCAAGAAGGATCTGCCCTTGGCAACGCAGAACAGCATTC
TCAAGCAAGCCGGCCTGAAGTGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14446.23 Da        Isoelectric Point: 4.8986

>AT59241 WP_058895168.1 NZ_CP013737:c2137616-2137218 [Herbaspirillum rubrisubalbicans M1]
MLYPIYVHKDAHSAYGATFPDFPGCFAGADELQLLPAAAQEAVEAHFHGEAEPIPSPSAPEDWADDEHFQGGYWMLVEID
LSRVNAKAVRLNVSLPQGLVTRIDAVAQARRMSRSAFLALAAEHEMQAGSRR

Download         Length: 399 bp

>AT59241 NZ_CP013737:c2137616-2137218 [Herbaspirillum rubrisubalbicans M1]
ATGCTCTACCCCATCTACGTCCACAAGGACGCCCACAGTGCCTATGGCGCCACCTTCCCCGATTTCCCCGGCTGCTTTGC
CGGGGCGGACGAACTGCAACTCCTGCCCGCAGCCGCGCAGGAAGCAGTGGAGGCGCATTTTCACGGGGAGGCCGAGCCCA
TCCCTAGCCCGAGCGCCCCTGAAGACTGGGCCGACGATGAACACTTCCAGGGTGGTTATTGGATGCTGGTGGAAATCGAT
CTGTCGCGCGTCAACGCCAAGGCGGTACGGCTCAACGTCAGTCTGCCGCAGGGCCTGGTGACGCGCATCGATGCCGTGGC
ACAGGCACGACGCATGTCGCGCTCGGCCTTCCTGGCCCTGGCGGCCGAGCACGAAATGCAGGCCGGGAGCCGTCGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U3LKM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3L9Y5

References