Detailed information of TA system TA059237

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 861435..862021
• Replicon: chromosome
• Accession: NZ_CP013732
• Organism: Burkholderia cepacia JBK9

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: P350_RS39495
• Protein ID: WP_081052120.1
• Coordinates: 861435..861818 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A6J5DI86
• Locus tag: P350_RS35805
• Protein ID: WP_031397730.1
• Coordinates: 861815..862021 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P350_RS35795	857755..859410	-	1656	WP_059241768.1	phage tail protein	-
P350_RS35800	860461..861036	+	576	WP_155627345.1	hypothetical protein	-
P350_RS39495	861435..861818	-	384	WP_081052120.1	PIN domain-containing protein	Toxin
P350_RS35805	861815..862021	-	207	WP_031397730.1	DUF2191 domain-containing protein	Antitoxin
P350_RS35810	862346..864334	+	1989	WP_059242468.1	RNA polymerase sigma factor RpoD	-
P350_RS35815	864733..865224	-	492	Protein_690	helix-turn-helix domain-containing protein	-
P350_RS35820	865402..866892	-	1491	WP_059240538.1	ISNCY family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-115)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14345.67 Da
• Isoelectric Point: 6.8524

>T59237 WP_081052120.1 NZ_CP013732:c861818-861435 [Burkholderia cepacia JBK9]
MSVLVDTSVWVEHFWRPLPALIQLLRIDNVLTHPLVILELTCGTPPEPRARTLGDLALLRQTRLATSGEVADWIERERLY
GRGCGAVDCTLLASVLLTPSTRLWTRDRRLAQLAEQFGVHYVPPDLH

Nucleotide

• Length: 384 bp

>T59237 NZ_CP013732:c861818-861435 [Burkholderia cepacia JBK9]
ATGAGTGTCTTGGTCGACACGTCCGTGTGGGTCGAGCATTTCTGGCGGCCACTACCGGCGCTTATCCAACTTCTGCGCAT
CGATAACGTCCTTACACATCCACTGGTGATACTTGAGCTCACGTGCGGGACGCCGCCCGAACCGCGGGCGCGAACGCTGG
GAGATCTCGCGTTACTACGCCAAACGCGCCTCGCGACGTCAGGCGAAGTAGCGGACTGGATCGAGCGGGAACGGCTGTAT
GGGCGCGGATGCGGTGCCGTGGATTGCACGCTGCTGGCATCGGTGCTGTTGACCCCGAGCACCCGGCTCTGGACGCGCGA
TCGGCGGCTCGCGCAACTGGCGGAGCAATTCGGGGTTCACTACGTACCGCCTGACTTGCATTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7323.40 Da
• Isoelectric Point: 6.2465

>AT59237 WP_031397730.1 NZ_CP013732:c862021-861815 [Burkholderia cepacia JBK9]
MRTTVTVDDTLYARALELAEPGMPPADLFRAALETFVRVQAGQRLAALGGRAPDMADVPRRAPEATAR

Nucleotide

• Length: 207 bp

>AT59237 NZ_CP013732:c862021-861815 [Burkholderia cepacia JBK9]
ATGCGTACCACCGTCACCGTCGACGACACTCTCTATGCGCGCGCACTCGAACTCGCCGAACCGGGCATGCCGCCGGCTGA
CCTGTTCCGGGCGGCACTTGAAACCTTCGTGCGTGTCCAGGCCGGCCAACGCCTGGCCGCTCTGGGCGGTCGCGCGCCCG
ACATGGCAGATGTCCCACGCCGCGCCCCTGAGGCAACCGCCCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A6J5DI86