Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2723583..2725431 Replicon chromosome
Accession NZ_CP013731
Organism Burkholderia cepacia JBK9

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag P350_RS29500 Protein ID WP_059240104.1
Coordinates 2723583..2724494 (+) Length 304 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag P350_RS29505 Protein ID WP_059240106.1
Coordinates 2724574..2725431 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P350_RS29470 2718973..2720052 - 1080 WP_059240094.1 porin -
P350_RS29475 2720489..2720806 + 318 WP_006489883.1 non-heme iron oxygenase ferredoxin subunit -
P350_RS29480 2720808..2721119 + 312 WP_059240097.1 hypothetical protein -
P350_RS29485 2721174..2722244 + 1071 WP_059240099.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
P350_RS29490 2722237..2723007 + 771 WP_059240101.1 SDR family oxidoreductase -
P350_RS29495 2723037..2723564 + 528 WP_059240103.1 cupin domain-containing protein -
P350_RS29500 2723583..2724494 + 912 WP_059240104.1 alpha/beta fold hydrolase Toxin
P350_RS29505 2724574..2725431 + 858 WP_059240106.1 IclR family transcriptional regulator Antitoxin
P350_RS29510 2725428..2726225 + 798 WP_059240109.1 SDR family oxidoreductase -
P350_RS29515 2726218..2727885 + 1668 WP_059240111.1 thiamine pyrophosphate-binding protein -
P350_RS29520 2727878..2728693 + 816 WP_059240112.1 aspartate dehydrogenase -
P350_RS29525 2728766..2730256 + 1491 WP_059240114.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(56-284)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 304 a.a.        Molecular weight: 31032.27 Da        Isoelectric Point: 7.7324

>T59236 WP_059240104.1 NZ_CP013731:2723583-2724494 [Burkholderia cepacia JBK9]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAGEAGAQHAGRTLPVVLLHGIGSGAASWVRQLDTLGASR
RVLAWDAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSA
PAETRESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRT
AVAVGANDAITPPAACERIAAAAHVALQVIPQAGHAGYVEAPAVYSALIDGFCRQCDQQRGLG

Download         Length: 912 bp

>T59236 NZ_CP013731:2723583-2724494 [Burkholderia cepacia JBK9]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGCTACCGTGAAGCCGGCGCAGGCGAGGCCGGCGCGCAGCATGCGGGCCGCACGC
TGCCCGTCGTGCTGCTGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTCCGCCAGCTCGACACGCTCGGCGCATCGCGG
CGCGTGCTCGCATGGGATGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCTGCCGCCGATTACGC
GGCATCGCTGAACGCGTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCGTTG
CGGGCGGTCTCGCCCGCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCTGCTGGCGGTTATGGCAGCGCA
CCGGCCGAAACGCGCGAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCCGAGCA
GCGCAGCGGCAACATGCTGTCCGGTTTCGCGAACGAGGAGGCGAAGGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGC
CGGCCGGCTACGCGCAGGCCACGCATCTGCTCGCGAACGCAGACCTCGCGACCGATCTCGCCGGCTTCCGCGGCCGCACG
GCCGTGGCCGTCGGTGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGCGCT
GCAGGTGATTCCGCAAGCCGGTCATGCCGGCTACGTGGAAGCGCCGGCCGTTTATTCCGCACTGATCGACGGCTTCTGCC
GCCAGTGCGACCAACAGCGGGGGCTGGGATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31416.88 Da        Isoelectric Point: 6.5058

>AT59236 WP_059240106.1 NZ_CP013731:2724574-2725431 [Burkholderia cepacia JBK9]
MSEPLQQNESENAKAEANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTSATPETVDALYDMIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT59236 NZ_CP013731:2724574-2725431 [Burkholderia cepacia JBK9]
ATGAGCGAACCGCTGCAACAAAACGAATCCGAAAACGCGAAGGCCGAAGCCAACTATGTGGTGCCGGGCCTCGAACGCGG
GCTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAACTGTCGAAACGGCTGGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCTTGCCGGTGATCGA
AAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATTCGCGTGAACGTCGGCACGCGCCTGCCCGCGCATGCGACGACCCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCACGCACTGTATCCGGAAGGCGCGCTGAACCGGATGACGAGCGCGAC
GCCGGAAACGGTCGACGCGTTGTACGACATGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTGGTGACGGCGCCGGTGCGCAACGAGACGCAGAGGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGTCCGGAGATCGACGCGGCGTTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTGAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References