Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2531058..2531716 Replicon chromosome
Accession NZ_CP013731
Organism Burkholderia cepacia JBK9

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P350_RS28675 Protein ID WP_059239811.1
Coordinates 2531297..2531716 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P350_RS28670 Protein ID WP_155627303.1
Coordinates 2531058..2531300 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P350_RS28645 2526333..2526728 - 396 WP_059240944.1 type II toxin-antitoxin system VapC family toxin -
P350_RS28650 2526725..2526964 - 240 WP_059239804.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
P350_RS28655 2527056..2527739 - 684 WP_059239806.1 Fe2+-dependent dioxygenase -
P350_RS28660 2527736..2528491 - 756 WP_059239808.1 sel1 repeat family protein -
P350_RS28665 2528495..2530738 - 2244 WP_059239809.1 TonB-dependent siderophore receptor -
P350_RS28670 2531058..2531300 + 243 WP_155627303.1 Arc family DNA-binding protein Antitoxin
P350_RS28675 2531297..2531716 + 420 WP_059239811.1 type II toxin-antitoxin system VapC family toxin Toxin
P350_RS28680 2531846..2533141 - 1296 WP_059239813.1 aspartate carbamoyltransferase -
P350_RS28685 2533376..2533510 + 135 WP_021158165.1 entericidin A/B family lipoprotein -
P350_RS28690 2533606..2534154 - 549 WP_059239815.1 hypothetical protein -
P350_RS28695 2534353..2535321 - 969 WP_059240947.1 DMT family transporter -
P350_RS28700 2535488..2536282 - 795 WP_059239817.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(10-47)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15058.33 Da        Isoelectric Point: 5.7457

>T59235 WP_059239811.1 NZ_CP013731:2531297-2531716 [Burkholderia cepacia JBK9]
MILVDTNVMSEPLRREPSAAVIEWLDAQNVETLFLSAISLAELRFGVAGLPEGRRRDWLHQGIEQRVVPLFRGRILPFDD
AASKAYASLCARARAAGTALAVVDGHIAATAEANGLIVATRDVAPFEAVGLRVIDPWAR

Download         Length: 420 bp

>T59235 NZ_CP013731:2531297-2531716 [Burkholderia cepacia JBK9]
ATGATCCTGGTTGATACGAACGTCATGTCCGAACCGTTGCGGCGCGAGCCGAGCGCGGCGGTGATCGAGTGGCTCGATGC
TCAGAACGTCGAGACGCTGTTTCTATCCGCGATCAGTCTCGCGGAATTGCGGTTCGGCGTGGCGGGATTGCCGGAAGGGC
GCAGGCGTGACTGGCTGCATCAAGGCATCGAGCAGCGTGTCGTTCCATTGTTTCGAGGCCGGATCCTGCCGTTCGACGAT
GCGGCGAGCAAAGCGTACGCGAGCCTTTGCGCGCGGGCGCGTGCCGCAGGCACCGCGCTTGCCGTCGTCGATGGTCACAT
TGCCGCGACGGCCGAGGCAAACGGCCTGATCGTGGCGACACGCGACGTCGCGCCGTTCGAGGCGGTGGGGCTTCGGGTCA
TCGACCCGTGGGCGCGATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8694.97 Da        Isoelectric Point: 10.6626

>AT59235 WP_155627303.1 NZ_CP013731:2531058-2531300 [Burkholderia cepacia JBK9]
IRPVVTVRNLPDEVHRALRIRAARHGRSTEAEVRDILEQAVLPGGRLKLGTLLAGIGRAAGDADFSVPRDKTPTEPMGFE

Download         Length: 243 bp

>AT59235 NZ_CP013731:2531058-2531300 [Burkholderia cepacia JBK9]
ATCAGGCCGGTGGTCACCGTTCGAAATTTGCCTGATGAAGTGCATCGCGCACTTCGGATTCGCGCGGCCCGGCACGGGCG
CAGCACCGAAGCCGAGGTGCGCGACATCCTCGAGCAGGCCGTCTTGCCAGGTGGGCGGCTCAAGTTGGGAACGTTGCTGG
CGGGAATCGGGCGAGCGGCCGGCGATGCCGACTTCAGCGTCCCGCGCGACAAGACGCCAACCGAGCCGATGGGCTTCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References