Detailed information of TA system TA059234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 599028..599669
• Replicon: chromosome
• Accession: NZ_CP013731
• Organism: Burkholderia cepacia JBK9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: P350_RS20050
• Protein ID: WP_059237391.1
• Coordinates: 599028..599366 (+)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A132EUP1
• Locus tag: P350_RS20055
• Protein ID: WP_009692881.1
• Coordinates: 599370..599669 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P350_RS20040	595579..597012	-	1434	WP_059237389.1	aldehyde dehydrogenase family protein	-
P350_RS20045	597042..598682	-	1641	WP_059237390.1	acetolactate synthase large subunit	-
P350_RS20050	599028..599366	+	339	WP_059237391.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
P350_RS20055	599370..599669	+	300	WP_009692881.1	putative addiction module antidote protein	Antitoxin
P350_RS20060	599719..601005	-	1287	WP_059237392.1	DUF445 domain-containing protein	-
P350_RS20065	601113..602333	-	1221	WP_059237393.1	FAD-dependent oxidoreductase	-
P350_RS20070	602323..602649	-	327	WP_059237394.1	non-heme iron oxygenase ferredoxin subunit	-
P350_RS20075	602667..603143	-	477	WP_059237395.1	aromatic-ring-hydroxylating dioxygenase subunit beta	-
P350_RS20080	603158..604429	-	1272	WP_059240780.1	Rieske 2Fe-2S domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (26-98)

Antitoxin

• Uncharacterized protein HI1420 (5-93)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12623.54 Da
• Isoelectric Point: 9.9829

>T59234 WP_059237391.1 NZ_CP013731:599028-599366 [Burkholderia cepacia JBK9]
MVDILQSVPYSAPTFSVRTTAVFDAWFAGLSDRIARRRIQARIDRLSMGNPGDWKSAGSPIVEMRIDHGPGYRVYYVRRG
MRWVILLCGGDKSTQQADIRAAHAMLAHLDME

Nucleotide

• Length: 339 bp

>T59234 NZ_CP013731:599028-599366 [Burkholderia cepacia JBK9]
ATGGTTGACATACTGCAATCGGTGCCCTACAGTGCGCCTACGTTCAGCGTCCGGACCACCGCCGTCTTCGACGCCTGGTT
TGCCGGCCTGTCCGATCGCATCGCCAGGCGCCGCATCCAGGCGCGCATCGACCGCCTCTCGATGGGCAATCCGGGCGACT
GGAAATCCGCCGGCTCGCCCATCGTCGAAATGCGCATCGATCACGGGCCCGGCTATCGCGTCTACTACGTCCGGCGTGGA
ATGCGCTGGGTGATCCTGCTCTGCGGCGGCGATAAATCGACGCAACAGGCCGATATCCGCGCCGCACACGCGATGCTTGC
GCACCTCGACATGGAGTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10690.10 Da
• Isoelectric Point: 6.6384

>AT59234 WP_009692881.1 NZ_CP013731:599370-599669 [Burkholderia cepacia JBK9]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Nucleotide

• Length: 300 bp

>AT59234 NZ_CP013731:599370-599669 [Burkholderia cepacia JBK9]
ATGGACAAGATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGAAGACGACATGGCCGACTACTTCGACGC
GTGCCTGCAGGAGGCCGGCGACGATCCAGCCTTCATCGCGCACGCGCTAGGCGTGATCGCCCGTGCACGCGGCATGTCGC
AGGTCGCGCGCGATGCGGGGCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCGAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAGTTGCACGGCTCGAAAGCGCACGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A132EUP1