Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2290795..2291468 Replicon chromosome
Accession NZ_CP013730
Organism Burkholderia cepacia JBK9

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag P350_RS10585 Protein ID WP_059234244.1
Coordinates 2290795..2291211 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag P350_RS10590 Protein ID WP_059234245.1
Coordinates 2291208..2291468 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P350_RS10560 2286402..2286779 + 378 WP_059234232.1 cobalamin biosynthesis protein -
P350_RS10565 2286814..2287416 + 603 WP_059234234.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
P350_RS10570 2287419..2288723 + 1305 WP_059234236.1 cobyrinate a,c-diamide synthase -
P350_RS10575 2288750..2289289 - 540 WP_059234239.1 outer membrane protein assembly factor BamE -
P350_RS10580 2289455..2290618 - 1164 WP_059234241.1 amidohydrolase -
P350_RS10585 2290795..2291211 - 417 WP_059234244.1 PIN domain-containing protein Toxin
P350_RS10590 2291208..2291468 - 261 WP_059234245.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
P350_RS10595 2291719..2292735 - 1017 WP_059234247.1 acetyltransferase -
P350_RS10600 2292735..2293574 - 840 WP_059234249.1 N(5)-hydroxyornithine transformylase PvdF -
P350_RS10605 2293661..2295925 - 2265 WP_059234251.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-130)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14495.76 Da        Isoelectric Point: 9.8741

>T59233 WP_059234244.1 NZ_CP013730:c2291211-2290795 [Burkholderia cepacia JBK9]
VTTLYMLHTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAMTYAEMRFGAVGKKASPKHAELVTAFVSRLDGVLPWDTA
AVDATAAIRAGLAARGTPIGTNDASIAGHAIAAGAVLVTHNGRAFGRVAGLSLEDWAA

Download         Length: 417 bp

>T59233 NZ_CP013730:c2291211-2290795 [Burkholderia cepacia JBK9]
GTGACCACGCTCTACATGCTCCATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCCCCCGTGGTGCTGTCGCGGTT
GCAGTCGTGCGTGAATGCGCAACACCGGATCGTCGTGTCGGCCATGACCTACGCCGAGATGCGGTTCGGCGCGGTTGGCA
AGAAGGCGTCGCCGAAGCACGCGGAACTCGTGACGGCGTTTGTTTCGCGGCTCGATGGCGTGCTGCCGTGGGATACGGCG
GCCGTCGATGCCACGGCCGCGATTCGTGCCGGTCTCGCCGCGCGCGGCACGCCGATCGGCACGAACGATGCGTCGATCGC
GGGGCATGCGATTGCGGCCGGCGCGGTGCTCGTCACCCATAATGGCCGCGCATTCGGCCGTGTCGCGGGGTTGTCGCTCG
AGGATTGGGCGGCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9775.01 Da        Isoelectric Point: 4.5112

>AT59233 WP_059234245.1 NZ_CP013730:c2291468-2291208 [Burkholderia cepacia JBK9]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFANEPLADADFLAERPAVIESGRFDLSDADA
PTESNR

Download         Length: 261 bp

>AT59233 NZ_CP013730:c2291468-2291208 [Burkholderia cepacia JBK9]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAATCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACGTTGCTGCTGAGGCCGGTACGGCCAACGTGGCTGTCGTTCGCGAACGAAC
CGCTGGCCGATGCCGATTTCCTTGCCGAACGCCCGGCCGTCATCGAGTCCGGCCGCTTCGACCTGTCCGACGCCGACGCG
CCGACGGAGTCCAACCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References