Detailed information of TA system TA059232

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 302511..303148
• Replicon: chromosome
• Accession: NZ_CP013730
• Organism: Burkholderia cepacia JBK9

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: P350_RS01465
• Protein ID: WP_059232770.1
• Coordinates: 302511..302912 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: P350_RS01470
• Protein ID: WP_059236527.1
• Coordinates: 302912..303148 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P350_RS01455	299880..301022	+	1143	WP_059236525.1	alginate lyase family protein	-
P350_RS01460	301053..302441	+	1389	WP_059232769.1	L-serine ammonia-lyase	-
P350_RS01465	302511..302912	-	402	WP_059232770.1	type II toxin-antitoxin system VapC family toxin	Toxin
P350_RS01470	302912..303148	-	237	WP_059236527.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
P350_RS01475	303501..305204	+	1704	WP_059232771.1	thiamine pyrophosphate-binding protein	-
P350_RS01480	305201..306307	+	1107	WP_059236529.1	hypothetical protein	-
P350_RS01485	306398..307432	-	1035	WP_059232772.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14918.03 Da
• Isoelectric Point: 5.7368

>T59232 WP_059232770.1 NZ_CP013730:c302912-302511 [Burkholderia cepacia JBK9]
MPRYMLDTNMCIYLIKNQPEQVARRFAQCYSGDVVMSAITYAELEYGVAACANPVRERRNLAALIEDIPVAPFDTAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFASYPGLRLGNWLND

Nucleotide

• Length: 402 bp

>T59232 NZ_CP013730:c302912-302511 [Burkholderia cepacia JBK9]
ATGCCGCGTTACATGCTCGACACCAACATGTGCATCTATCTGATCAAGAATCAGCCGGAGCAGGTCGCGAGACGGTTCGC
GCAGTGTTACAGCGGAGATGTCGTGATGTCGGCGATCACCTATGCCGAACTCGAGTACGGTGTCGCGGCGTGCGCGAATC
CTGTCCGCGAGCGTCGCAATCTTGCTGCGCTGATCGAGGACATCCCCGTTGCTCCGTTCGACACGGCGGCCGCGCAAGCA
TACGGCCCGGTTCGGGAAGCGACGCGCGAGCGGAAGAAGGATCATCTCGACAAACTGATCGCCGCGCATGCGGTGTCGCT
CGATGTGGTCCTGGTGACCAACAACGAACGGGATTTTGCGAGTTATCCGGGATTGCGGCTGGGGAACTGGTTGAACGATT
GA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8996.03 Da
• Isoelectric Point: 5.1585

>AT59232 WP_059236527.1 NZ_CP013730:c303148-302912 [Burkholderia cepacia JBK9]
VHTTRVFRNGNSQAVRIPADLAYERSDMELEIERVGDEIRIRPTRRPLTHVLEKFANFGPDFMAEGRGDQEQAEREGL

Nucleotide

• Length: 237 bp

>AT59232 NZ_CP013730:c303148-302912 [Burkholderia cepacia JBK9]
GTGCATACCACCAGGGTATTTCGGAACGGTAACTCGCAGGCCGTGCGGATTCCTGCGGACCTTGCCTATGAGCGCAGCGA
CATGGAACTCGAAATCGAGCGGGTGGGCGACGAAATCCGTATTCGGCCCACTCGGAGACCTTTGACCCACGTACTCGAGA
AGTTCGCGAACTTCGGGCCGGATTTCATGGCCGAGGGGCGCGGCGATCAGGAGCAGGCCGAGCGCGAGGGCTTGTGA