Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1838005..1838525 Replicon chromosome
Accession NZ_CP013714
Organism Staphylococcus equorum strain C2014

Toxin (Protein)


Gene name TsdT Uniprot ID A0A1B1G849
Locus tag AVJ22_RS08955 Protein ID WP_065338433.1
Coordinates 1838005..1838217 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID J9GWP4
Locus tag AVJ22_RS08960 Protein ID WP_002507096.1
Coordinates 1838232..1838525 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AVJ22_RS08940 1833466..1834536 - 1071 WP_065338431.1 D-alanine--D-alanine ligase -
AVJ22_RS08945 1834811..1836025 + 1215 WP_065338432.1 rod shape-determining protein RodA -
AVJ22_RS08950 1836165..1837481 + 1317 WP_065337371.1 ISL3 family transposase -
AVJ22_RS14445 1837650..1837790 - 141 WP_002507098.1 hypothetical protein -
AVJ22_RS08955 1838005..1838217 - 213 WP_065338433.1 heavy-metal-associated domain-containing protein Toxin
AVJ22_RS08960 1838232..1838525 - 294 WP_002507096.1 copper-sensing transcriptional repressor CsoR Antitoxin
AVJ22_RS08965 1838669..1840153 + 1485 WP_065338434.1 cardiolipin synthase -
AVJ22_RS08970 1840273..1840923 + 651 WP_065338435.1 HD domain-containing protein -
AVJ22_RS08975 1840992..1841861 - 870 WP_002507093.1 membrane protein insertase YidC -
AVJ22_RS08980 1841949..1842587 - 639 WP_065338436.1 thiamine phosphate synthase -
AVJ22_RS08985 1842587..1843378 - 792 WP_065339164.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(18-67)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8144.19 Da        Isoelectric Point: 4.7260

>T59228 WP_065338433.1 NZ_CP013714:c1838217-1838005 [Staphylococcus equorum]
VVTKVIYISGIENETQQKHIEQRLKQLHGVHQVNIEIESNNGKIFIDFETPASLNNLEKEVYDLGYEILY

Download         Length: 213 bp

>T59228 NZ_CP013714:c1838217-1838005 [Staphylococcus equorum]
GTGGTAACCAAAGTAATTTATATTTCCGGTATAGAAAATGAAACACAACAAAAACATATTGAACAGCGGCTTAAGCAATT
ACACGGTGTACACCAAGTCAACATAGAAATAGAAAGCAATAATGGCAAAATTTTCATTGATTTTGAAACCCCTGCAAGTT
TAAATAATTTAGAAAAAGAAGTTTATGATTTAGGATATGAAATTTTATATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11195.87 Da        Isoelectric Point: 6.4791

>AT59228 WP_002507096.1 NZ_CP013714:c1838525-1838232 [Staphylococcus equorum]
MAEIQKAHHSEQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNGVATKLLDHHMKSCIMEKVEQGQQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT59228 NZ_CP013714:c1838525-1838232 [Staphylococcus equorum]
ATGGCGGAAATACAAAAAGCGCATCACTCAGAACAAATTAAATCTAATTTAAAATCAAGATTAAATCGTATAGAAGGCCA
AGTGAGAGCAATTAATCGCATGGTAGATGAAGATGTTTATTGTGATGACGTGCTCACACAAATTAGAGCCACTCGATCGG
CTTTAAATGGTGTTGCTACTAAATTATTAGACCATCATATGAAAAGTTGTATTATGGAAAAAGTAGAGCAGGGTCAACAA
GAAGAAGCTATGGAAGAACTATTGGTTACATTTCAAAAATTAATGAAGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1G849

Antitoxin

Source ID Structure
AlphaFold DB J9GWP4

References