Detailed information of TA system TA059209

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 708755..709597
• Replicon: chromosome
• Accession: NZ_CP013711
• Organism: Klebsiella pneumoniae strain J1

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: AU361_RS03520
• Protein ID: WP_058836880.1
• Coordinates: 708755..709132 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: AU361_RS03525
• Protein ID: WP_077265480.1
• Coordinates: 709184..709597 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AU361_RS03495	704928..705837	-	910	Protein_659	integrase arm-type DNA-binding domain-containing protein	-
AU361_RS03500	706166..706963	-	798	WP_058836876.1	helix-turn-helix transcriptional regulator	-
AU361_RS03505	707107..707952	-	846	WP_058836877.1	DUF4942 domain-containing protein	-
AU361_RS03510	708034..708237	-	204	WP_058836878.1	DUF957 domain-containing protein	-
AU361_RS03515	708300..708758	-	459	WP_058836879.1	hypothetical protein	-
AU361_RS03520	708755..709132	-	378	WP_058836880.1	TA system toxin CbtA family protein	Toxin
AU361_RS03525	709184..709597	-	414	WP_077265480.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
AU361_RS03530	709566..709787	-	222	WP_058836881.1	DUF987 family protein	-
AU361_RS03535	709808..710287	-	480	WP_058836882.1	DNA repair protein RadC	-
AU361_RS03540	710299..710763	-	465	WP_058836883.1	antirestriction protein	-
AU361_RS03545	711118..711936	-	819	WP_058836884.1	DUF945 domain-containing protein	-
AU361_RS03550	712098..713690	-	1593	Protein_670	IS66 family transposase	-
AU361_RS03560	713721..714071	-	351	WP_009309933.1	IS66 family insertion sequence element accessory protein TnpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	696240..732612	36372

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (33-132)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14113.94 Da
• Isoelectric Point: 6.6349

>T59209 WP_058836880.1 NZ_CP013711:c709132-708755 [Klebsiella pneumoniae]
MQTQPLSSRQEASPRPSPVDIWQQLLSHLLDRHYGLTLNDTPFGHDCVIQEHIDAGISLCDAVNVIVEKYDLVRTDRPGF
SAETQSPLISSIDILRARKATGLMTRNDYRTVTHITTGKYREVQP

Nucleotide

• Length: 378 bp

>T59209 NZ_CP013711:c709132-708755 [Klebsiella pneumoniae]
ATGCAAACCCAACCGCTATCCTCCAGGCAGGAGGCTTCGCCACGCCCGTCACCGGTGGATATCTGGCAGCAGCTTCTGAG
TCACCTGCTGGATCGTCACTACGGTCTGACGCTTAACGACACGCCATTTGGTCACGATTGCGTGATTCAGGAGCATATCG
ACGCGGGTATCTCACTGTGCGATGCCGTGAATGTTATCGTGGAAAAGTACGATCTGGTGCGCACCGACCGTCCCGGTTTC
AGCGCAGAAACACAGTCGCCGCTTATCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACCCGCAA
CGACTACAGAACGGTGACCCACATCACCACCGGTAAATACCGTGAGGTGCAGCCATGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 14936.01 Da
• Isoelectric Point: 6.8319

>AT59209 WP_077265480.1 NZ_CP013711:c709597-709184 [Klebsiella pneumoniae]
MSSCAASRSINVNLRKAKLSNEIPAVNHDIAEPWWGLKPTVTPCFGARLVQEGNQVHYLADRASITGQFSEADLRHLDQA
FPVLLKQLELMLVSGELNPHHQHGVTLYAKGLTCEADSLGSHGYIYIAIYPTPAATA

Nucleotide

• Length: 414 bp

>AT59209 NZ_CP013711:c709597-709184 [Klebsiella pneumoniae]
ATGTCGTCCTGCGCAGCGTCACGCTCAATTAACGTTAATTTAAGGAAAGCTAAATTGTCGAATGAAATACCGGCAGTAAA
CCACGATATCGCTGAACCCTGGTGGGGCCTTAAGCCCACCGTCACACCGTGCTTTGGCGCACGACTGGTGCAGGAGGGCA
ACCAGGTGCACTATCTCGCCGACCGCGCCAGCATCACCGGTCAGTTCAGCGAGGCGGATTTACGCCATCTTGACCAAGCC
TTTCCGGTACTACTCAAACAGCTGGAATTGATGCTGGTTTCCGGTGAACTCAATCCTCACCATCAGCACGGCGTTACGCT
CTACGCAAAAGGGTTGACCTGCGAAGCCGATTCACTCGGCTCGCATGGCTACATTTATATTGCGATTTATCCAACGCCTG
CAGCAACCGCGTAA