Detailed information of TA system TA059176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/PIN-RelB
• Location: 938001..938854
• Replicon: chromosome
• Accession: NZ_CP013673
• Organism: Bifidobacterium longum strain 35624

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V6XWY1
• Locus tag: B624_RS03825
• Protein ID: WP_007054468.1
• Coordinates: 938363..938854 (+)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: B624_RS03820
• Protein ID: WP_058101837.1
• Coordinates: 938001..938363 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B624_RS03815	935156..937855	+	2700	WP_058101838.1	aconitate hydratase AcnA	-
B624_RS03820	938001..938363	+	363	WP_058101837.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
B624_RS03825	938363..938854	+	492	WP_007054468.1	PIN domain-containing protein	Toxin
B624_RS03830	938914..941019	-	2106	WP_058101836.1	DUF262 domain-containing protein	-
B624_RS03835	941109..941750	-	642	WP_007052627.1	GNAT family N-acetyltransferase	-
B624_RS03840	941790..942515	-	726	WP_007056206.1	response regulator transcription factor	-
B624_RS03845	942550..943782	-	1233	WP_007056207.1	sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	878057..983916	105859

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-141)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-53)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18328.91 Da
• Isoelectric Point: 4.5590

>T59176 WP_007054468.1 NZ_CP013673:938363-938854 [Bifidobacterium longum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNITLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Nucleotide

• Length: 492 bp

>T59176 NZ_CP013673:938363-938854 [Bifidobacterium longum]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTCGATACCAACGTACTGTTGGACTATTTGCTCCATCGCGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACATTACGTTGTTGTGCGCGTCATTGTCGCTGAAGGATA
TCGCATACCTATCATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCGGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATCGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAACTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCACTGGAATAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13988.05 Da
• Isoelectric Point: 5.0733

>AT59176 WP_058101837.1 NZ_CP013673:938001-938363 [Bifidobacterium longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGISVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRAD

Nucleotide

• Length: 363 bp

>AT59176 NZ_CP013673:938001-938363 [Bifidobacterium longum]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCAT
ATCGGTGAGTGACGTAATCCGGTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTACACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATGCGTATTACAACATGAAGAGGGCCGATTGA

Structures

Toxin

• AlphaFold DB: V6XWY1