Detailed information of TA system TA059175

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1613207..1613819
• Replicon: chromosome
• Accession: NZ_CP013672
• Organism: Streptococcus pyogenes strain AP53

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: AUQ45_RS08185
• Protein ID: WP_014635711.1
• Coordinates: 1613484..1613819 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: AUQ45_RS08180
• Protein ID: WP_002988079.1
• Coordinates: 1613207..1613494 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AUQ45_RS08155	1608397..1609380	-	984	WP_014635708.1	tagatose-bisphosphate aldolase	-
AUQ45_RS08160	1609384..1610313	-	930	WP_002982751.1	tagatose-6-phosphate kinase	-
AUQ45_RS08165	1610361..1610876	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
AUQ45_RS08170	1610911..1611339	-	429	WP_014635709.1	galactose-6-phosphate isomerase subunit LacA	-
AUQ45_RS08175	1611784..1612557	+	774	WP_014635710.1	DeoR/GlpR family DNA-binding transcription regulator	-
AUQ45_RS08180	1613207..1613494	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
AUQ45_RS08185	1613484..1613819	+	336	WP_014635711.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AUQ45_RS10035	1613971..1614441	+	471	WP_021733374.1	site-specific integrase	-
AUQ45_RS10040	1614404..1614952	+	549	WP_181879157.1	site-specific integrase	-
AUQ45_RS08195	1615072..1615464	-	393	WP_002982716.1	30S ribosomal protein S9	-
AUQ45_RS08200	1615485..1615931	-	447	WP_002982710.1	50S ribosomal protein L13	-
AUQ45_RS08205	1616149..1616355	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
AUQ45_RS08210	1616352..1616858	-	507	WP_002988070.1	hypothetical protein	-
AUQ45_RS08215	1616994..1617854	-	861	WP_002982687.1	DegV family protein	-
AUQ45_RS08220	1617951..1618469	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13173.94 Da
• Isoelectric Point: 5.6809

>T59175 WP_014635711.1 NZ_CP013672:1613484-1613819 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T59175 NZ_CP013672:1613484-1613819 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT59175 WP_002988079.1 NZ_CP013672:1613207-1613494 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT59175 NZ_CP013672:1613207-1613494 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94