Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-yefM/Txe-RelB |
| Location | 245186..245715 | Replicon | chromosome |
| Accession | NZ_CP013667 | ||
| Organism | Coxiella burnetii strain 3262 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q83AB3 |
| Locus tag | AUR58_RS01415 | Protein ID | WP_005769718.1 |
| Coordinates | 245440..245715 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | Q83AB4 |
| Locus tag | AUR58_RS01410 | Protein ID | WP_005769716.1 |
| Coordinates | 245186..245440 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AUR58_RS01375 | 240288..241064 | + | 777 | WP_017253343.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
| AUR58_RS11735 | 241071..241154 | + | 84 | Protein_255 | hypothetical protein | - |
| AUR58_RS01380 | 241177..241611 | + | 435 | WP_010958580.1 | universal stress protein | - |
| AUR58_RS01385 | 241780..242154 | + | 375 | WP_005769706.1 | hypothetical protein | - |
| AUR58_RS01390 | 242199..242897 | + | 699 | WP_010958581.1 | outer membrane beta-barrel protein | - |
| AUR58_RS01395 | 242961..243902 | + | 942 | WP_005769709.1 | S49 family peptidase | - |
| AUR58_RS01400 | 243915..244790 | + | 876 | WP_017253342.1 | symmetrical bis(5'-nucleosyl)-tetraphosphatase | - |
| AUR58_RS12320 | 244766..244879 | + | 114 | Protein_261 | type II toxin-antitoxin system YoeB family toxin | - |
| AUR58_RS01405 | 244939..245073 | + | 135 | WP_010958583.1 | hypothetical protein | - |
| AUR58_RS01410 | 245186..245440 | + | 255 | WP_005769716.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| AUR58_RS01415 | 245440..245715 | + | 276 | WP_005769718.1 | Txe/YoeB family addiction module toxin | Toxin |
| AUR58_RS01420 | 245688..246173 | - | 486 | WP_005769725.1 | dihydrofolate reductase | - |
| AUR58_RS01425 | 246170..246973 | - | 804 | WP_017253341.1 | epoxyqueuosine reductase QueH | - |
| AUR58_RS01430 | 247169..247456 | + | 288 | WP_005769730.1 | acylphosphatase | - |
| AUR58_RS01435 | 247432..247986 | - | 555 | WP_005769732.1 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase | - |
| AUR58_RS01440 | 247999..248943 | - | 945 | WP_010958586.1 | methionyl-tRNA formyltransferase | - |
| AUR58_RS01445 | 249110..249382 | + | 273 | WP_012220006.1 | hypothetical protein | - |
| AUR58_RS01450 | 249379..250398 | - | 1020 | WP_046036886.1 | IS110-like element IS1111A family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 249379..250398 | 1019 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 11150.86 Da Isoelectric Point: 9.6762
>T59169 WP_005769718.1 NZ_CP013667:245440-245715 [Coxiella burnetii]
MQISFTPEAWEDYLYWQKFDKKMLRRINELIKDAMHEPFSGKGKPEPLKFELQGYWSRRLDQEHRLVYKVLDDSLMIIAA
RFHYNRLNSKN
MQISFTPEAWEDYLYWQKFDKKMLRRINELIKDAMHEPFSGKGKPEPLKFELQGYWSRRLDQEHRLVYKVLDDSLMIIAA
RFHYNRLNSKN
Download Length: 276 bp
>T59169 NZ_CP013667:245440-245715 [Coxiella burnetii]
ATGCAAATTTCCTTCACGCCCGAAGCCTGGGAAGATTATTTATATTGGCAAAAATTCGACAAAAAAATGCTTCGACGCAT
TAATGAACTCATTAAGGATGCTATGCACGAGCCTTTTTCCGGAAAGGGAAAGCCAGAACCTTTAAAATTTGAATTACAAG
GATATTGGTCAAGACGATTAGATCAAGAACATCGATTGGTCTACAAAGTTTTAGACGATTCGTTAATGATTATCGCCGCA
AGATTTCACTATAATCGCCTTAATTCTAAAAACTGA
ATGCAAATTTCCTTCACGCCCGAAGCCTGGGAAGATTATTTATATTGGCAAAAATTCGACAAAAAAATGCTTCGACGCAT
TAATGAACTCATTAAGGATGCTATGCACGAGCCTTTTTCCGGAAAGGGAAAGCCAGAACCTTTAAAATTTGAATTACAAG
GATATTGGTCAAGACGATTAGATCAAGAACATCGATTGGTCTACAAAGTTTTAGACGATTCGTTAATGATTATCGCCGCA
AGATTTCACTATAATCGCCTTAATTCTAAAAACTGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9624.25 Da Isoelectric Point: 10.4802
>AT59169 WP_005769716.1 NZ_CP013667:245186-245440 [Coxiella burnetii]
MNVVTFSELRAQLKKILDLSADQHEPVVVKRPNKETMVILSLRDFEALKETAYLLSNEANAARLRQSIRSLKQGKAQKKK
LMED
MNVVTFSELRAQLKKILDLSADQHEPVVVKRPNKETMVILSLRDFEALKETAYLLSNEANAARLRQSIRSLKQGKAQKKK
LMED
Download Length: 255 bp
>AT59169 NZ_CP013667:245186-245440 [Coxiella burnetii]
ATGAACGTAGTTACTTTTAGCGAACTCAGGGCGCAACTTAAAAAAATCTTGGATCTTTCCGCCGATCAACACGAACCTGT
CGTCGTTAAACGGCCAAATAAAGAAACCATGGTCATTTTATCTTTACGCGACTTTGAGGCTCTAAAAGAAACAGCTTATC
TCTTAAGTAACGAAGCTAATGCGGCCCGTCTTCGTCAGTCTATCCGCAGCTTAAAACAAGGCAAGGCACAAAAAAAGAAA
TTAATGGAAGATTAA
ATGAACGTAGTTACTTTTAGCGAACTCAGGGCGCAACTTAAAAAAATCTTGGATCTTTCCGCCGATCAACACGAACCTGT
CGTCGTTAAACGGCCAAATAAAGAAACCATGGTCATTTTATCTTTACGCGACTTTGAGGCTCTAAAAGAAACAGCTTATC
TCTTAAGTAACGAAGCTAATGCGGCCCGTCTTCGTCAGTCTATCCGCAGCTTAAAACAAGGCAAGGCACAAAAAAAGAAA
TTAATGGAAGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|