Detailed information of TA system TA059169

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/Txe-RelB
• Location: 245186..245715
• Replicon: chromosome
• Accession: NZ_CP013667
• Organism: Coxiella burnetii strain 3262

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q83AB3
• Locus tag: AUR58_RS01415
• Protein ID: WP_005769718.1
• Coordinates: 245440..245715 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: Q83AB4
• Locus tag: AUR58_RS01410
• Protein ID: WP_005769716.1
• Coordinates: 245186..245440 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AUR58_RS01375	240288..241064	+	777	WP_017253343.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
AUR58_RS11735	241071..241154	+	84	Protein_255	hypothetical protein	-
AUR58_RS01380	241177..241611	+	435	WP_010958580.1	universal stress protein	-
AUR58_RS01385	241780..242154	+	375	WP_005769706.1	hypothetical protein	-
AUR58_RS01390	242199..242897	+	699	WP_010958581.1	outer membrane beta-barrel protein	-
AUR58_RS01395	242961..243902	+	942	WP_005769709.1	S49 family peptidase	-
AUR58_RS01400	243915..244790	+	876	WP_017253342.1	symmetrical bis(5'-nucleosyl)-tetraphosphatase	-
AUR58_RS12320	244766..244879	+	114	Protein_261	type II toxin-antitoxin system YoeB family toxin	-
AUR58_RS01405	244939..245073	+	135	WP_010958583.1	hypothetical protein	-
AUR58_RS01410	245186..245440	+	255	WP_005769716.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
AUR58_RS01415	245440..245715	+	276	WP_005769718.1	Txe/YoeB family addiction module toxin	Toxin
AUR58_RS01420	245688..246173	-	486	WP_005769725.1	dihydrofolate reductase	-
AUR58_RS01425	246170..246973	-	804	WP_017253341.1	epoxyqueuosine reductase QueH	-
AUR58_RS01430	247169..247456	+	288	WP_005769730.1	acylphosphatase	-
AUR58_RS01435	247432..247986	-	555	WP_005769732.1	D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase	-
AUR58_RS01440	247999..248943	-	945	WP_010958586.1	methionyl-tRNA formyltransferase	-
AUR58_RS01445	249110..249382	+	273	WP_012220006.1	hypothetical protein	-
AUR58_RS01450	249379..250398	-	1020	WP_046036886.1	IS110-like element IS1111A family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	249379..250398	1019

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11150.86 Da
• Isoelectric Point: 9.6762

>T59169 WP_005769718.1 NZ_CP013667:245440-245715 [Coxiella burnetii]
MQISFTPEAWEDYLYWQKFDKKMLRRINELIKDAMHEPFSGKGKPEPLKFELQGYWSRRLDQEHRLVYKVLDDSLMIIAA
RFHYNRLNSKN

Nucleotide

• Length: 276 bp

>T59169 NZ_CP013667:245440-245715 [Coxiella burnetii]
ATGCAAATTTCCTTCACGCCCGAAGCCTGGGAAGATTATTTATATTGGCAAAAATTCGACAAAAAAATGCTTCGACGCAT
TAATGAACTCATTAAGGATGCTATGCACGAGCCTTTTTCCGGAAAGGGAAAGCCAGAACCTTTAAAATTTGAATTACAAG
GATATTGGTCAAGACGATTAGATCAAGAACATCGATTGGTCTACAAAGTTTTAGACGATTCGTTAATGATTATCGCCGCA
AGATTTCACTATAATCGCCTTAATTCTAAAAACTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9624.25 Da
• Isoelectric Point: 10.4802

>AT59169 WP_005769716.1 NZ_CP013667:245186-245440 [Coxiella burnetii]
MNVVTFSELRAQLKKILDLSADQHEPVVVKRPNKETMVILSLRDFEALKETAYLLSNEANAARLRQSIRSLKQGKAQKKK
LMED

Nucleotide

• Length: 255 bp

>AT59169 NZ_CP013667:245186-245440 [Coxiella burnetii]
ATGAACGTAGTTACTTTTAGCGAACTCAGGGCGCAACTTAAAAAAATCTTGGATCTTTCCGCCGATCAACACGAACCTGT
CGTCGTTAAACGGCCAAATAAAGAAACCATGGTCATTTTATCTTTACGCGACTTTGAGGCTCTAAAAGAAACAGCTTATC
TCTTAAGTAACGAAGCTAATGCGGCCCGTCTTCGTCAGTCTATCCGCAGCTTAAAACAAGGCAAGGCACAAAAAAAGAAA
TTAATGGAAGATTAA

Structures

Toxin

• AlphaFold DB: Q83AB3

Antitoxin

• AlphaFold DB: Q83AB4