Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1875928..1876454 | Replicon | chromosome |
| Accession | NZ_CP013662 | ||
| Organism | Escherichia coli strain 08-00022 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | CP48_RS10970 | Protein ID | WP_000323025.1 |
| Coordinates | 1875928..1876215 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | CP48_RS10975 | Protein ID | WP_000534858.1 |
| Coordinates | 1876215..1876454 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CP48_RS10930 | 1870952..1871167 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| CP48_RS32215 | 1871387..1871557 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| CP48_RS10935 | 1871921..1872136 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| CP48_RS10940 | 1872437..1872649 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| CP48_RS31405 | 1872704..1872793 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| CP48_RS10945 | 1873071..1873823 | - | 753 | WP_001047135.1 | antitermination protein | - |
| CP48_RS10950 | 1873837..1874886 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| CP48_RS10955 | 1874888..1875166 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| CP48_RS10960 | 1875233..1875484 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| CP48_RS10965 | 1875701..1875856 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| CP48_RS10970 | 1875928..1876215 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| CP48_RS10975 | 1876215..1876454 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| CP48_RS28890 | 1876479..1876784 | + | 306 | WP_071527819.1 | hypothetical protein | - |
| CP48_RS10980 | 1876987..1877319 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| CP48_RS10985 | 1877756..1879096 | - | 1341 | WP_000589012.1 | ISNCY family transposase | - |
| CP48_RS10990 | 1879130..1879549 | - | 420 | WP_001151196.1 | DUF977 family protein | - |
| CP48_RS10995 | 1879590..1880555 | - | 966 | WP_000054504.1 | hypothetical protein | - |
| CP48_RS11000 | 1880536..1881057 | - | 522 | WP_000705349.1 | hypothetical protein | - |
| CP48_RS11005 | 1881041..1881268 | - | 228 | WP_000476993.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1837351..1888952 | 51601 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T59123 WP_000323025.1 NZ_CP013662:c1876215-1875928 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T59123 NZ_CP013662:c1876215-1875928 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT59123 WP_000534858.1 NZ_CP013662:c1876454-1876215 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT59123 NZ_CP013662:c1876454-1876215 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|