Detailed information of TA system TA059113

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2013968..2014450
• Replicon: chromosome
• Accession: NZ_CP013661
• Organism: Planococcus kocurii strain ATCC 43650

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5B0CN43
• Locus tag: AUO94_RS09940
• Protein ID: WP_058384066.1
• Coordinates: 2013968..2014231 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A5B0CN16
• Locus tag: AUO94_RS09945
• Protein ID: WP_058384067.1
• Coordinates: 2014238..2014450 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AUO94_RS09910	2009233..2010132	+	900	WP_058384060.1	ATP-binding cassette domain-containing protein	-
AUO94_RS09915	2010119..2011327	+	1209	WP_058384061.1	ABC transporter permease	-
AUO94_RS09920	2011679..2012131	-	453	WP_058384062.1	GNAT family N-acetyltransferase	-
AUO94_RS09925	2012150..2012329	-	180	WP_058384063.1	hypothetical protein	-
AUO94_RS09930	2012387..2012587	-	201	WP_058384064.1	hypothetical protein	-
AUO94_RS17270	2012649..2012789	-	141	WP_156423942.1	hypothetical protein	-
AUO94_RS09935	2013030..2013326	+	297	WP_058384065.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
AUO94_RS17275	2013680..2013757	-	78	Protein_1903	AbrB family transcriptional regulator	-
AUO94_RS09940	2013968..2014231	-	264	WP_058384066.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AUO94_RS09945	2014238..2014450	-	213	WP_058384067.1	hypothetical protein	Antitoxin
AUO94_RS17065	2014687..2015649	-	963	WP_082707526.1	DUF3885 domain-containing protein	-
AUO94_RS09955	2015696..2015983	-	288	WP_058384068.1	hypothetical protein	-
AUO94_RS17420	2016228..2016701	+	474	WP_058384069.1	hypothetical protein	-
AUO94_RS09965	2016761..2017141	-	381	Protein_1909	VOC family protein	-
AUO94_RS09970	2017440..2018128	+	689	Protein_1910	copper homeostasis protein CutC	-
AUO94_RS09975	2018402..2018911	-	510	WP_058384070.1	MepB family protein	-
AUO94_RS17425	2018985..2019235	-	251	Protein_1912	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-68)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10334.04 Da
• Isoelectric Point: 9.6404

>T59113 WP_058384066.1 NZ_CP013661:c2014231-2013968 [Planococcus kocurii]
MYAVHFSDVALKKLKKMDRYQASLLIGWIEKNLKDTDDPRIQGKAFVENHKGKWRYRVGDYRILALIEDEKIIITIIDVG
HRKDIYE

Nucleotide

• Length: 264 bp

>T59113 NZ_CP013661:c2014231-2013968 [Planococcus kocurii]
ATGTATGCAGTTCATTTCTCAGATGTCGCGTTGAAGAAATTAAAAAAGATGGACCGGTACCAGGCCTCTCTCCTGATTGG
CTGGATTGAAAAGAACTTGAAGGATACCGACGATCCACGAATACAAGGCAAGGCATTTGTTGAAAACCACAAAGGCAAGT
GGCGTTACCGGGTTGGTGATTACCGTATTTTAGCGTTGATCGAAGACGAAAAGATCATTATTACCATTATCGATGTTGGG
CATCGAAAAGATATCTACGAATAA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 8039.14 Da
• Isoelectric Point: 4.4734

>AT59113 WP_058384067.1 NZ_CP013661:c2014450-2014238 [Planococcus kocurii]
MATISLRVDDRDSKLIRDYAKLKNTSVSDLMRNAIIEKIEDELDVENFDRVLATMETTHSLDDVKKELGL

Nucleotide

• Length: 213 bp

>AT59113 NZ_CP013661:c2014450-2014238 [Planococcus kocurii]
ATGGCCACTATTTCTTTGCGTGTGGATGACCGCGACAGCAAACTCATCCGCGACTACGCCAAACTGAAAAACACATCTGT
TTCGGATTTGATGCGGAATGCCATCATCGAGAAGATTGAAGATGAACTGGATGTCGAAAACTTTGACCGGGTCCTTGCCA
CTATGGAAACAACCCATTCCTTGGATGACGTCAAAAAAGAATTGGGTTTATAA

Structures

Toxin

• AlphaFold DB: A0A5B0CN43

Antitoxin

• AlphaFold DB: A0A5B0CN16