Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 1239563..1240202 Replicon chromosome
Accession NZ_CP013661
Organism Planococcus kocurii strain ATCC 43650

Toxin (Protein)


Gene name pemK Uniprot ID E7RK71
Locus tag AUO94_RS06085 Protein ID WP_008432415.1
Coordinates 1239563..1239913 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A5B0CU35
Locus tag AUO94_RS06090 Protein ID WP_058386377.1
Coordinates 1239918..1240202 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AUO94_RS06050 1235130..1235912 - 783 WP_058386371.1 RNA polymerase sigma factor SigB -
AUO94_RS06055 1235890..1236360 - 471 WP_058386372.1 anti-sigma B factor RsbW -
AUO94_RS06060 1236362..1236691 - 330 WP_058386373.1 anti-sigma factor antagonist -
AUO94_RS06065 1236788..1237789 - 1002 WP_058386374.1 PP2C family protein-serine/threonine phosphatase -
AUO94_RS06070 1237802..1238203 - 402 WP_058386375.1 anti-sigma regulatory factor -
AUO94_RS06075 1238206..1238571 - 366 WP_177167575.1 STAS domain-containing protein -
AUO94_RS06080 1238568..1239395 - 828 WP_058386376.1 STAS domain-containing protein -
AUO94_RS06085 1239563..1239913 - 351 WP_008432415.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
AUO94_RS06090 1239918..1240202 - 285 WP_058386377.1 hypothetical protein Antitoxin
AUO94_RS06095 1240246..1241403 - 1158 WP_058386378.1 alanine racemase -
AUO94_RS06100 1241419..1241772 - 354 WP_058386379.1 holo-ACP synthase -
AUO94_RS06105 1241841..1242449 + 609 WP_058386380.1 rhomboid family intramembrane serine protease -
AUO94_RS06110 1242493..1244004 - 1512 WP_058386970.1 PH domain-containing protein -
AUO94_RS06115 1243997..1244476 - 480 WP_058386381.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12880.97 Da        Isoelectric Point: 5.8817

>T59112 WP_008432415.1 NZ_CP013661:c1239913-1239563 [Planococcus kocurii]
MIVKRGDVFFAELSPVVGSEQGGTRPVLVIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEINAKKYGFERDSVILLEQL
RTIDKSRLTDKITQLDDTLMEKVDEALEISVGLVKF

Download         Length: 351 bp

>T59112 NZ_CP013661:c1239913-1239563 [Planococcus kocurii]
TTGATTGTAAAACGCGGAGATGTTTTTTTTGCGGAATTATCGCCAGTCGTCGGGTCTGAGCAGGGTGGGACCCGACCTGT
ACTGGTGATTCAAAACGATATAGGGAATCGTTTTAGTCCCACTGTTATTATTGCAGCAATCACGGCGCAAATTCAAAAAG
CCAAATTACCGACTCATGTAGAAATCAACGCCAAGAAATACGGCTTTGAGCGCGATTCCGTTATTTTGCTAGAACAATTG
CGAACCATTGACAAGTCGCGACTGACCGACAAAATTACGCAGCTTGACGACACTTTGATGGAAAAAGTAGACGAAGCATT
AGAAATCAGCGTAGGTCTTGTTAAATTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10764.16 Da        Isoelectric Point: 6.3231

>AT59112 WP_058386377.1 NZ_CP013661:c1240202-1239918 [Planococcus kocurii]
VYEKSKTKEVVVKMPKQFISELTTHSNEHVQESGDYIYVSTSRVTKNLYDSYHIREAMIKGYVEMSQINLSIACECSHAE
YEAEHMTVRLVSGG

Download         Length: 285 bp

>AT59112 NZ_CP013661:c1240202-1239918 [Planococcus kocurii]
GTGTACGAGAAGTCAAAGACAAAAGAAGTGGTTGTGAAAATGCCAAAGCAATTTATTTCAGAGTTGACAACTCATTCAAA
TGAGCATGTCCAAGAAAGTGGAGATTATATTTATGTTTCCACAAGCCGGGTGACAAAAAATCTGTATGACTCATATCATA
TTCGAGAAGCGATGATCAAAGGCTACGTGGAGATGTCTCAAATCAATCTATCGATTGCTTGTGAATGTTCTCACGCTGAG
TATGAAGCGGAGCATATGACTGTCCGACTCGTAAGCGGAGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7DUM1

Antitoxin

Source ID Structure
AlphaFold DB A0A5B0CU35

References