Detailed information of TA system TA059105

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4048853..4049673
• Replicon: chromosome
• Accession: NZ_CP013658
• Organism: Escherichia coli strain uk_P46212

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: AUO99_RS21210
• Protein ID: WP_001054379.1
• Coordinates: 4049416..4049673 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: AUO99_RS21205
• Protein ID: WP_000123957.1
• Coordinates: 4048853..4049404 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AUO99_RS21180	4044547..4045860	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
AUO99_RS21185	4045872..4046150	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
AUO99_RS21190	4046147..4047268	-	1122	WP_000010833.1	M42 family metallopeptidase	-
AUO99_RS29800	4047513..4047629	-	117	Protein_3863	VOC family protein	-
AUO99_RS21195	4047667..4047927	-	261	WP_000077645.1	hypothetical protein	-
AUO99_RS21200	4048055..4048801	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
AUO99_RS21205	4048853..4049404	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
AUO99_RS21210	4049416..4049673	-	258	WP_001054379.1	YjhX family toxin	Toxin
AUO99_RS28020	4050050..4050214	-	165	Protein_3868	GNAT family N-acetyltransferase	-
AUO99_RS21225	4051457..4052563	+	1107	Protein_3870	helicase YjhR	-
AUO99_RS21230	4053146..4054126	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T59105 WP_001054379.1 NZ_CP013658:c4049673-4049416 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T59105 NZ_CP013658:c4049673-4049416 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT59105 WP_000123957.1 NZ_CP013658:c4049404-4048853 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT59105 NZ_CP013658:c4049404-4048853 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030