59092

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1322450..1323281 Replicon chromosome
Accession NZ_CP013658
Organism Escherichia coli strain uk_P46212

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag AUO99_RS08025 Protein ID WP_000854815.1
Coordinates 1322907..1323281 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag AUO99_RS08020 Protein ID WP_001280918.1
Coordinates 1322450..1322818 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AUO99_RS07975 1317539..1318285 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
AUO99_RS07980 1318368..1318718 + 351 Protein_1370 hypothetical protein -
AUO99_RS07985 1318734..1319144 + 411 WP_000846703.1 hypothetical protein -
AUO99_RS07990 1319365..1320183 + 819 WP_001542275.1 DUF945 domain-containing protein -
AUO99_RS07995 1320183..1320428 + 246 WP_001164966.1 hypothetical protein -
AUO99_RS08000 1320522..1320995 + 474 WP_001542276.1 antirestriction protein -
AUO99_RS08005 1321011..1321487 + 477 WP_001186200.1 RadC family protein -
AUO99_RS08010 1321550..1321771 + 222 WP_000692345.1 DUF987 domain-containing protein -
AUO99_RS08015 1321790..1322434 + 645 WP_000086752.1 hypothetical protein -
AUO99_RS08020 1322450..1322818 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AUO99_RS08025 1322907..1323281 + 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
AUO99_RS08030 1323278..1323472 + 195 WP_000988600.1 hypothetical protein -
AUO99_RS29650 1323485..1323598 + 114 WP_001161660.1 DUF957 domain-containing protein -
AUO99_RS29215 1323887..1324033 - 147 Protein_1382 transposase domain-containing protein -
AUO99_RS29220 1324087..1324269 + 183 WP_001296208.1 hypothetical protein -
AUO99_RS08045 1324370..1324699 - 330 WP_000450409.1 DUF496 family protein -
AUO99_RS08050 1324871..1325929 - 1059 WP_001200889.1 FUSC family protein -
AUO99_RS08055 1326127..1326600 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
AUO99_RS08060 1326719..1327885 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T59092 WP_000854815.1 NZ_CP013658:1322907-1323281 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T59092 NZ_CP013658:1322907-1323281 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT59092 WP_001280918.1 NZ_CP013658:1322450-1322818 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT59092 NZ_CP013658:1322450-1322818 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References