Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 2548234..2548744 Replicon chromosome
Accession NZ_CP013650
Organism Lacimicrobium alkaliphilum strain YelD216

Toxin (Protein)


Gene name relB Uniprot ID A0A0U3ACR6
Locus tag AT746_RS11580 Protein ID WP_062480469.1
Coordinates 2548234..2548497 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0U3AXJ1
Locus tag AT746_RS11585 Protein ID WP_062480471.1
Coordinates 2548490..2548744 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT746_RS11570 2543596..2546277 + 2682 WP_062480465.1 cation-transporting P-type ATPase -
AT746_RS11575 2546436..2547959 - 1524 WP_062480467.1 carboxypeptidase -
AT746_RS11580 2548234..2548497 - 264 WP_062480469.1 Txe/YoeB family addiction module toxin Toxin
AT746_RS11585 2548490..2548744 - 255 WP_062480471.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
AT746_RS11590 2549198..2549989 - 792 WP_156413681.1 hypothetical protein -
AT746_RS11595 2550004..2551173 - 1170 WP_062480475.1 RDD family protein -
AT746_RS11600 2551219..2552391 - 1173 WP_062480478.1 VWA domain-containing protein -
AT746_RS11605 2552391..2553227 - 837 WP_062480480.1 MoxR family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10281.70 Da        Isoelectric Point: 9.4082

>T59064 WP_062480469.1 NZ_CP013650:c2548497-2548234 [Lacimicrobium alkaliphilum]
MSNRLLSWTDEAWNSYLYWQTQDKKTLKRINKLIADVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVDDGAITI
ISCRYHY

Download         Length: 264 bp

>T59064 NZ_CP013650:c2548497-2548234 [Lacimicrobium alkaliphilum]
ATGAGTAACAGGTTGTTGTCATGGACTGATGAAGCCTGGAACAGCTATTTATACTGGCAAACGCAAGATAAAAAGACGCT
TAAACGTATCAACAAGTTAATTGCCGATGTTAAACGTTCTCCGTTTGAGGGGATTGGCAAACCGGAACCGTTGAAAGAGA
ATTTAGCTGGTTTCTGGTCGCGAAGAATCGACGATACAAACAGGCTGGTTTATGCCGTTGACGATGGTGCGATTACAATA
ATTTCCTGTCGTTACCATTATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9513.65 Da        Isoelectric Point: 4.7914

>AT59064 WP_062480471.1 NZ_CP013650:c2548744-2548490 [Lacimicrobium alkaliphilum]
MKIVSFTEARNGLKAVLDSVINDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIAQYREGKTSQRE
LLDE

Download         Length: 255 bp

>AT59064 NZ_CP013650:c2548744-2548490 [Lacimicrobium alkaliphilum]
ATGAAGATTGTCTCTTTTACGGAAGCCAGAAATGGTTTGAAAGCAGTTTTGGACAGTGTAATAAACGATGCAGACACTAC
TGTAATTACACGTCGTGATTCTGAAGATGCTGTGGTCATGTCCCTGGATTATTACAACAGTTTAATGGAAACCGTGCATT
TACTCCGTTCGCCTGCAAATGCTGAGCACCTGAACAGATCTATAGCTCAATACAGAGAGGGGAAAACTTCTCAGCGGGAA
TTATTAGATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U3ACR6

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3AXJ1

References