59054

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1295127..1295788 Replicon chromosome
Accession NZ_CP013630
Organism Rhizobium sp. N324

Toxin (Protein)


Gene name vapB Uniprot ID A0A235AT81
Locus tag AMK05_RS06175 Protein ID WP_049734513.1
Coordinates 1295127..1295534 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A235AUY2
Locus tag AMK05_RS06180 Protein ID WP_049734512.1
Coordinates 1295534..1295788 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMK05_RS06155 1291770..1292777 + 1008 WP_064837487.1 asparaginase -
AMK05_RS06160 1292778..1293533 - 756 WP_064837489.1 DeoR/GlpR family DNA-binding transcription regulator -
AMK05_RS06165 1293674..1294030 + 357 WP_064837491.1 hypothetical protein -
AMK05_RS06170 1294461..1295081 + 621 WP_064837494.1 glutathione S-transferase family protein -
AMK05_RS06175 1295127..1295534 - 408 WP_049734513.1 type II toxin-antitoxin system VapC family toxin Toxin
AMK05_RS06180 1295534..1295788 - 255 WP_049734512.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AMK05_RS06185 1295872..1296522 - 651 WP_064841293.1 glutathione S-transferase family protein -
AMK05_RS06190 1296685..1297662 - 978 WP_064841294.1 phosphodiester glycosidase family protein -
AMK05_RS06195 1297812..1298282 + 471 WP_064837496.1 GNAT family N-acetyltransferase -
AMK05_RS06200 1298360..1298554 - 195 WP_064837498.1 hypothetical protein -
AMK05_RS06205 1298667..1299563 + 897 WP_064837500.1 LysR family transcriptional regulator -
AMK05_RS06210 1299668..1300333 - 666 WP_064837502.1 glutathione S-transferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-61)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14783.01 Da        Isoelectric Point: 6.9903

>T59054 WP_049734513.1 NZ_CP013630:c1295534-1295127 [Rhizobium sp. N324]
MYLVDTNIVSEARRGTPQAVSWLRSVDPLSIHLSALTLGEIMRGIALKQRSDPKAAAHLAEWLRKLRHDHGARILPVTDQ
IAVEWGRIAAIRPRGDIDGLIAATAIVHDLIVVTRNVGDFNDTGASVIDPWEIPA

Download         Length: 408 bp

>T59054 NZ_CP013630:c1295534-1295127 [Rhizobium sp. N324]
ATGTATCTGGTCGATACCAATATCGTTTCGGAGGCGCGACGCGGCACGCCGCAGGCGGTTTCGTGGTTGCGCTCCGTCGA
TCCGCTGAGCATTCATCTGAGCGCCTTGACCCTTGGCGAGATCATGCGCGGCATTGCTCTCAAACAGAGGTCGGACCCGA
AGGCCGCCGCCCACCTCGCCGAGTGGCTACGCAAGCTGCGCCACGACCATGGCGCCCGCATCCTGCCGGTGACCGATCAG
ATCGCCGTGGAATGGGGCCGCATCGCCGCGATCCGGCCACGCGGCGATATCGACGGGCTGATCGCAGCGACCGCGATCGT
CCATGATCTGATCGTCGTCACCCGCAATGTCGGCGATTTCAACGACACCGGCGCATCGGTGATCGATCCTTGGGAGATAC
CGGCATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9312.45 Da        Isoelectric Point: 4.7872

>AT59054 WP_049734512.1 NZ_CP013630:c1295788-1295534 [Rhizobium sp. N324]
MEWQLQEAKNKFSKVVQKARDEGPQVVTLRGERTAVVLSARDYDALRAGRPSLVDDLLGGPTWDDELADAVEARVATPSR
NVTF

Download         Length: 255 bp

>AT59054 NZ_CP013630:c1295788-1295534 [Rhizobium sp. N324]
ATGGAATGGCAGCTGCAGGAGGCCAAGAACAAGTTTTCGAAAGTCGTGCAGAAGGCGCGAGATGAAGGACCGCAGGTGGT
GACGCTCCGCGGCGAGCGGACGGCTGTCGTGCTGTCCGCCCGCGACTATGACGCCCTGCGCGCCGGCCGGCCATCGCTGG
TCGACGACCTGCTCGGCGGCCCCACCTGGGACGACGAGCTTGCCGATGCGGTCGAAGCGCGCGTTGCGACGCCAAGCCGC
AACGTGACCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A235AT81

Antitoxin

Source ID Structure
AlphaFold DB A0A235AUY2

References