59040

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 904196..904672 Replicon chromosome
Accession NZ_CP013621
Organism Staphylococcus aureus strain RIVM3897

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag AUC50_RS04320 Protein ID WP_000052076.1
Coordinates 904196..904384 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag AUC50_RS04325 Protein ID WP_001059690.1
Coordinates 904412..904672 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AUC50_RS04290 900225..900707 + 483 WP_000824489.1 hypothetical protein -
AUC50_RS04295 901048..901734 + 687 WP_001574556.1 thermonuclease family protein -
AUC50_RS04300 902091..902291 + 201 WP_001059082.1 cold-shock protein -
AUC50_RS04305 902788..903006 - 219 WP_000005881.1 hypothetical protein -
AUC50_RS04310 903067..903351 - 285 WP_001004403.1 hypothetical protein -
AUC50_RS04315 903439..904008 - 570 WP_001106655.1 hypothetical protein -
AUC50_RS04320 904196..904384 - 189 WP_000052076.1 hypothetical protein Toxin
AUC50_RS04325 904412..904672 - 261 WP_001059690.1 hypothetical protein Antitoxin
AUC50_RS04330 905014..905217 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
AUC50_RS04335 905214..905450 - 237 WP_000368687.1 hypothetical protein -
AUC50_RS04340 905675..906256 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
AUC50_RS04345 906329..906946 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
AUC50_RS04350 907095..907589 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
AUC50_RS04355 907988..908410 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
AUC50_RS04360 908558..909274 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-272)

Antitoxin

AbiEi antitoxin C-terminal domain

(84-237)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T59040 WP_000052076.1 NZ_CP013621:c904384-904196 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T59040 NZ_CP013621:c904384-904196 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT59040 WP_001059690.1 NZ_CP013621:c904672-904412 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT59040 NZ_CP013621:c904672-904412 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References